Category Archives: Anti-Aging Medicine

Whether you have pain or want to improve your overall wellbeing, RiverView Health cupping services may be just what you need.

Cupping is an ancient form of therapeutic medicine with origins dating as far back as 1,550 B.C. Therapeutic cupping is applied to assist with pain management, inflammation, blood flow, and relaxation. The benefits are achieved by creating a negative pressure environment over the treatment area through suction. Various tools can be utilized, such as glass, silicone, bamboo, and pottery.

RiverView Health Physical Therapist Caitlyn Michno has been offering dry cupping and massage cupping in Crookston since January. She is a certified myofascial (muscle) cupping practitioner, utilizing silicone cups for patient safety and infection prevention measures.

Increased Movement, Less PainOne of the multiple benefits of therapeutic cupping is the ability to address myofascial adhesions, or sticky spots, in a patients layers of tissue/skin that occur following inflammation or scar tissue formation, Michno reported. The decompression that occurs through the negative pressure environment allows for increased fluid volume between the layers of skin, which helps break apart the adhesions to improve the movement of the layers of skin. Michno uses this approach when patients report pulling or tightness especially long after surgery.

I am grateful to report quite a bit of success with the practice, she shared What I have been most excited about is the noted improvements in patients with chronic low back pain, especially those who have undergone multiple surgeries and continue to suffer from disabling pain. This patient population in particular often has a significant amount of myofascial adhesions as a result of recurrent inflammation to the affected area and multiple surgical scars. Cupping has been the most effective intervention I have found to address the adhesions and tightness to the low back. The patients I have worked with have reported significant improvements in their day-to-day movement and pain.

According to Michno, cupping also helps to increase the brain and awareness of the treatment area. Studies have shown that people with chronic pain often have decreased sensory representation of that area of the body in their brain. By performing cupping therapy, we can increase blood flow and the brain awareness of that area, and with time, that leads to increased sensory representation of that area in the brain. If our brain is better able to identify what is going on in that area of chronic pain, it is better able to tell whether or not it needs to be in pain. This often leads to a reduction in pain

Along with relief comes some minor bruising, a common patient concern, according to Michno. The discoloration that occurs does not indicate injury or damage to that area. Instead, it tells us what sort of chemical response is occurring as a result of the treatment. The indicated chemical response does not change our treatment approach or course of treatment. In ancient times it was viewed as more significant and represented the effectiveness in withdrawing toxins and obtaining balance within the body.

Treatment for a Long List of AilmentsHealthy patients (anti-aging treatment, rejuvenation purpose) and those suffering from ailments find wellbeing and relief through cupping. Localized conditions that benefit from cupping therapy include headache, lower back pain, neck pain, and knee pain. Systemic illnesses aided through cupping therapy include hypertension, rheumatoid arthritis, diabetes mellitus, mental disorders, heart disease, hypertension, and infections. Cupping can treat skin diseases, respiratory, musculoskeletal, digestive, reproductive, and allergic conditions.

Benefits of cupping include:

Cupping is considered a manual therapy intervention and is billed and covered by insurance as part of a typical therapy visit.

If you are interested in relieving pain or gaining relaxation through cupping, call RiverViews Rehab Services Department at 281.9463.

Caitlyn Michno, DPT, provides dry cupping and massage cupping at RiverView Health.

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RIVERVIEW PATIENTS REPORT DECREASED PAIN WITH NEW CUPPING THERAPY - kroxam.com

Clarins USA

Yes, thats right. Amazon Prime Day 2021 is here, and not only has it rightfully returned to its original summertime spot after last years pandemic-related delay, but its also actually a month earlier than its original before-times slot and competitors are dropping their own version of Prime Day deals, including Walmart with its Days for Deals sale.

So, what does that mean for skincare aficionados? Well, for starters, now would be a good time to stock up on some cult favorites, like the award-winning Double Face Serum Complete Age Control Concentrate from Clarins. Normally priced at $127, Walmart is discounting it to $82. Hurry because this luxury item will sell out fast.

The much-loved anti-aging serum by the French luxury skincare brand packs as its name suggests twice the punch when it comes to addressing your age-related skincare concerns.

How so? Its unique two-phase formula is enriched with a whopping 21 plant extracts that, when simply put, improve your skins existing vital functions and tackle the major signs of aging: Fine lines, wrinkles, enlarged pores, and uneven skin tone. The result? A natural, healthy, and youthful glow something most of us are no doubt striving for after a year and more of sitting indoors behind phone and laptop screens.

Dont let terms like the hydric and lipidic system intimidate you. Well leave the complexities of the exact science to the pros at Clarins (and we thank them for what they do for our skin). When it comes down to it, the ingredients many of them organic incorporated in this little miracle bottle contain anti-aging properties by their very nature.

Take turmeric, one of the Double Serums shining stars, for example (it also happens to be similar in color to the now-classic bottle weve come to easily spot on shelves): The plant is not only an antioxidant but also a superb antiseptic and anti-inflammatory agent thats been used in Ayurvedic medicine for over 5,000 years. Where skin in particular is concerned, turmeric helps regulate communication between the skin and cells, promotes healing, and is one of the key players responsible for that glow weve been talking about.

Other antioxidant ingredients in Double Serum that you may recognize from your kitchen, like avocado, stimulate skin regeneration and keep your visage looking plump and supple, whereas banana safeguards your collagen levels to keep them in top condition. The nutrient-dense kiwi nourishes cells, while mango prevents skin from dehydration.

We could wax lyrical about each of the 21 plus ingredients and their benefits found in Clarins Double Serum, but the results speak for themselves and quickly, too. One of the serums selling points is that it not only works to keep you looking more youthful in the long run, it also delivers brighter, fresher results almost instantly, so youll be ready to step away from the screens and head out feeling summer-ready.

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Pigs Must Be Flying, Because this Award-Winning Face Serum is on Sale - The Manual

Whether you've recently noticed a few new wrinkles on your face or are suddenly feeling significantly older than your chronological age, there are countless reasons you might be looking to turn back the clock. However, even if you haven't exactly found the fountain of youth, you can both look and feel younger with just a few small changes to your routine. Read on to discover the anti-aging supplements recommended by registered dietitians. And for more supplements you may want to add to your routine, check out The One Vitamin Doctors Are Urging Everyone to Take Right Now.

Curcumin, a yellow compound found in turmeric, is a great way to fight free radical damage that leads to aging.

"Aging happens over time as our cells are exposed to free radicals and inflammation. When this happens, the structures involved in cell replication and lifespantelomeresshorten, so anything that can reduce inflammation and free radicals is helpful," says Alicia Galvin, RD, resident dietitian to Sovereign Laboratories.

"Curcumin activates certain proteins, like AMP-activated protein kinase (AMPK), which helps combat cellular damage and promotes longevity."

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Want to lose weight and turn back the clock in one fell swoop? Then you might want to add some EGCG to your diet.

"Epigallocatechin gallate (EGCG) is a polyphenol concentrated in green tea," Galvin explains. "It induces autophagy, the process by which your body removes damaged cellular material."

What's more, in a small study of 73 overweight and obese women published in BMC Complementary Medicine and Therapies, EGCG was found to reduce LDL or "bad" cholesterol and increase levels of leptin, a hormone associated with satiety.

If you want to look and feel younger, CoQ10 supplementation might just do the trick.

"CoQ10 declines as you age, and CoQ10 supplements help reduce the accumulation of free radicals that accelerate the aging process," Galvin says.

And if you want to protect your health, These Popular Supplements Have Hidden Dangers, Warn Experts.

Adding some resveratrola compound found in a number of red wine, red fruits, and peanuts, among other foodsto your regular routine is a great way to fight aging from the inside out.

"Resveratrol may promote longevity by activating genes called sirtuins," Galvin says. "This doesn't mean you can drink red wine and not age, but as a supplement, resveratrol can be very effective."

If you do like to wind down with wine at the end of the day, check out the One Surprising Side Effect of Drinking Red Wine for Women, Says New Study.

Vitamin D, a vitamin naturally synthesized through the skin by exposure to sunlight, can have profound anti-aging benefits in supplement form.

"Vitamin D allows the body to absorb calcium, which fuels bone health and may reduce the risk for fracture," says Diana Gariglio-Clelland, RD, a dietitian with Next Luxury.

Citing 2015 research published in the Journal of Advanced Research, Gariglio-Clelland notes that vitamin D has also been linked to reduced UV damage.

If you're eager to keep your body and brain healthy as you age, fish oil supplements are an excellent addition to your wellbeing arsenal.

"Fish oil supplements contain omega-3 fatty acids, known to protect our heart health and cognition, both of which are essential as we age," says Michelle Darian, MS, MPH, RD, a nutrition scientist at InsideTracker.

And for more easy ways to boost your brainpower, check out the 30 Best & Worst Foods for Your Brain.

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Best Supplements That Fight Aging, According to Experts - Eat This, Not That

Recent findings from a scientific study may just have discovered the holy grail of health. As confirmed by TRC Gen+, a recent study from Prof. Nikolaos Tzenios PH.D. has pinpointed the healthy diet plan which brings down bodyweight and boosts cardiovascular health markers. Head of the study, Prof Tzenios, is a respected industry professional and holds positions as Professor of Public Health, Fellow of the American Academy of Anti-Aging Medicine and Fellow of The Royal Society for Public Health (UK), among other high-level roles.

An open-label clinical study conducted by the well-regarded KGK Science Canada organisation explored the impact of Nics Keto Diet on cardiovascular health. The study looked at healthy women and men who had slightly elevated LDL cholesterol measurements for a 140 day period. On completion of the clinical study, KGK Science found that participants had a 4.41% lowering in the percentage of body fat.

Results also showed that those who had taken part in the study had seen an 8.55kg reduction in body weight overall. In addition, participants also recorded a significant drop in LDL and total cholesterol readings, after following the diet for 5 months. There was also an increase in good HDL cholesterol levels and an impressive drop in blood sugar levels.

In summary, the study from KGK Science indicates that following Nics Keto Diet could help to lower body weight, boost cardiovascular health, lower bad cholesterol levels and reduce blood sugar levels. As a result, its findings are sure to make waves in the health and nutrition sector.

https://ketoandorganic.com/

Jenny has been reporting on small business issues since 2001 where she held a number of freelance positions across the leading SME publications in the UK. Specialist subjects included SME financing and tax.

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Following a Nic's Keto Diet may improve cardiovascular health and reduce body weight - SMEbulletin

Bloomberg

(Bloomberg) -- The cyber-attack that crippled the nations biggest fuel pipeline this week triggered spot shortages of gasoline and a gusher of political rhetoric, with groups from across the political spectrum offering myriad, and contradictory, solutions.The oil industry says the answer is to invest in more fossil-fuel infrastructure, including refineries. Environmental groups think the key is more electric vehicles on the road and solar panels on the grid. A conservative think tank called the outage a wake-up call for pipeline protesters to stop. Even a coal group got involved, noting that its product doesnt need to be piped anywhere.Wind and solar power networks are by their very nature more distributed, more sensibly scaled, and more resilient than fossil fuel systems, Wenonah Hauter, executive director of the environmental group Food and Water Watch, said in a statement.The stark divisions reflect the increasingly vocal energy debate. The oil and gas industry has found itself on the defensive against growing calls to fight climate change by reducing consumption of its products. While many fossil fuel advocates agree that curbing greenhouse gases is critical, they point to the Colonial shutdown as a sign of the potential risks of making the green transition too quickly.Colonial Pipeline Co. began to restart the line Wednesday evening, after a ransomware attack caused the company to shut it down May 7. The pipeline delivers about 45% of the gasoline, jet fuel and diesel used on the East Coast.Whew, crisis averted, that pipeline is back up, tweeted Chris Horner, an attorney and former senior fellow at the Competitive Enterprise Institute. Now, back to our regularly scheduled agenda of shutting down pipelines.Conservatives have drawn links between the Colonial outage that transported refined fuels and President Joe Bidens opposition to the proposed Keystone XL oil pipeline that would have ferried tar sands crude from Alberta to Nebraska. Even a fully operational Keystone XL would have had no effect on fuel supplies during the Colonial outage, since it would carry minimally processed crude, not gasoline and other refined fuel.The Colonial Pipeline closure should serve as a wake-up call to pipeline protesters who pretend we dont need the energy transported by these pieces of critical infrastructure, opined the Center of the American Experiment, a Minnesota-based conservative think tank. We are as reliant upon oil and natural gas as we are water, and that reality isnt going to change anytime soon.Refining advocates also used the fuel shortages to highlight the decline in fuel-making capacity in the Northeast. Where the East Coast previously had 12 refineries, closures have dropped that number to four. By some estimates, the Atlantic Basin has lost a total of 1.5 million barrels per day of refining capacity since 2008, making the region more reliant on imports and fuel transported by Colonial.A New Jersey lawmaker pressed administration officials to address the decline during a briefing Wednesday. Each time a refinery closes, were losing the ability to fuel our defense, the unidentified lawmaker said, according to a person on the call.The coal industry, whose chief product is a rock that cant be carried by pipelines, used the incident to highlight the value of its fossil fuel. The National Mining Association, which represents companies such as Consol Energy Inc. and Peabody Energy Corp., promoted coal as a valuable insurance policy in an era of emerging and deceptively dangerous threats.Its becoming clear that pipelines and just-in-time fuel delivery are a particularly vulnerable link in the equation, the Washington-based trade group said in a statement Wednesday. The months of fuel stored on site at coal and nuclear power plants add a layer of security and resilience we have long taken for granted and continue to undervalue.Biden administration officials cited the crisis to highlight the presidents multi-trillion-dollar plans for investing in the nations highways, electric vehicle charging and the grid.This incident also reminds us that infrastructure is a national security issue, and the reality is that investing in world-class, modern and resilient infrastructure has always been central to ensuring our countrys economic security, our national security and, as were seeing right now, that includes cybersecurity, Transportation Secretary Pete Buttigieg said at a White House briefing.Energy Secretary Jennifer Granholm noted at least one group hasnt been affected by the pipeline outage and the fuel shortages it caused along the East Coast.If you drive an electric car this would not be affecting you, clearly, she said during a White House briefing Tuesday.For more articles like this, please visit us at bloomberg.comSubscribe now to stay ahead with the most trusted business news source.2021 Bloomberg L.P.

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Eating a Nic's Keto Healthy Fatty Diet Reduce Body Weight and Improve Cardiovascular Health Markers! - Yahoo Finance

Scientists have started to test whether natural killer, or NK, cells can be trained to go after hard-to-cure blood cancers in human patients. But making these sentinels of the innate immune system a potential boon to human health spans might be simpler: Rather than needing to be genetically engineered or primed with synthetic antibodies, they just need to be turned on.

In mice, researchers reported on Monday in the journal Med, activating NKT cells can eliminate the senescent cells partly responsible for many diseases of aging. If the results hold up, they could offer a promising alternative to senolytics experimental drugs that destroy these zombified cells that pile up and pollute your tissues as you get older. Although dozens of such drugs have postponed or even reversed diseases of aging in mouse experiments, clinical trials have thus far underwhelmed.

Its an interesting approach that works in experimental animals with two different conditions, said geriatrician James Kirkland of the Mayo Clinic, whose discovery that giving old mice senescent cell-crushing compounds makes the animals live longer, healthier lives, helped take senolytics from backwater to boomtown. Were going to need multiple ways of getting at senescent cells, he said. Any step forward is important, and this is quite a nice step forward. But he cautioned that a single senolytic strategy is unlikely to work for all age-related conditions.

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For decades, scientists had largely ignored senescent cells old and arrested in a permanent state of suspended animation dismissing them as a quirk of evolution, a clever way for the body to keep damaged cells from proliferating into cancer. But more recently, Kirkland and other researchers established that senescence is actually a driver of the decrepitude that comes with old age. As cells stop dividing, they dont exactly go dormant. In their zombie-like state, they start spewing a cocktail of toxic molecules that cause inflammation, damage surrounding tissues, and contribute to diseases like osteoarthritis, atherosclerosis, diabetes, and Alzheimers.

That realization spurred the creation of at least two dozen companies developing ways to systematically purge the body of senescent cells. Senolytics attracted this wave of investment because it promises a scintillating and fundamental shift in medicine away from the one-drug-one-target-one-disease paradigm of the last century, toward correcting a root cause behind many of them with a single treatment.

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One of those researchers is the new studys senior author, Anil Bhushan of the University of California, San Francisco. In 2019, his lab traced the progression of type 1 diabetes in mice and human pancreatic cells. They discovered that signatures of senescence preceded the onset of disease. When his team removed the senescent pancreatic cells in mice, their metabolism stabilized and their diabetes symptoms went away.

What Bhushan took away from that study was that senescence didnt just happen when the bodys biological clocks wound down too far. It occurred in acute diseases too. Thered been talk in the field that an immune surveillance system maintained tissue homeostasis, said Bhushan. We postulated that that system was failing in the disease state and gradually failing in aging, so the only time wed see senescent cells is when this system fails.

To test that hypothesis, his team first went looking for clues as to the identity of their indolent immune cells. By comparing the transcriptional profile which genes were turned on and off in senescent pancreatic cells to healthy ones, they uncovered that the senescent ones boosted production of their antigen-presenting machinery. These are the proteins that, if a cell were infected with a pathogen, would shuttle little bits of the bacteria or virus to its surface, displaying them for immune cells to find. Then they cross-referenced those results with an analysis of senescent stem cells that accumulate in the fat tissues of obese mice who are fed a chronic, high-fat diet. Those cells also upregulated antigen-presenting molecules, and one in particular: CD1d. That was the lock, said Bhushan. And once wed found it, the key was then obvious.

Only one kind of immune cell binds to CD1d invariant natural killer T cells, or iNKTs. Comprising less than 1% of all peripheral blood immune cells, iNKTs are rare but critical components of the bodys surveillance system, scanning for infected and defective cells in need of removal. When they find them, iNKTs expel torrents of cytokines, which signal to other immune cells to do the dirty work. Bhushan figured that something was interfering with that process. And though he wasnt sure what it was, he knew there was a way to fix it.

In the early 1990s, Japanese scientists from Kirin Brewerys pharmaceutical research lab, looking for anticancer treatments in the porous bodies of marine sponges collected in the Okinawan sea, purified a lipid compound called -galactosylceramide. And they discovered that when CD1d grabs onto this -GalCer lipid, it turns on iNKTs like crazy in mice.

So Bhushans team shot up some of their diet-induced obese mice with -GalCer. Within days, the levels of senescent cells in the mouse fat tissues had dropped. So did their fasting glucose. Their insulin sensitivity also improved. Their metabolism started to look normal.

To see how generalizable the effect was, they repeated the experiment with mice whose lung tissues had been damaged by a chemotherapy drug a common model for idiopathic pulmonary fibrosis, a serious and incurable human lung disease, and one of the nastier complications of Covid-19. In those mice, -GalCer successfully activated iNKTs, again resulting in the removal of senescent cells. The treated mice had fewer damaged cells, and they also lived longer than the control group.

Finally, Bhushan and his colleagues looked at how well activated iNKT cells could tell senescent human cells from healthy ones when cultured together. After 18 hours, 100% of the senescent cells had been destroyed; the vast majority of healthy cells went unscathed. That could give the iNKT approach a potential advantage over the senolytics drugs already in development.

Most of them are repackaged cancer drugs that work by flipping on senescent cells self-destruct buttons. But because zombie cells share a lot of molecular features with their fully animated counterparts, those drugs run the risk of creating lots of collateral damage. Clinical trials of one such drug, 17-DMAG, were abandoned due to toxic side effects in the kidney and brain. Other groups are trying to solve this by engineering a different kind of immune cell, the CAR-T cell, to become a better anti-aging treatment. But CAR-Ts come with their own dangerous side effects and are expensive to make.

Bhushan is optimistic that by returning the cells best trained to suss out senescent cells to the ranks of active immune duty, both these safety and cost concerns can be ameliorated. We have this built in specificity of the immune cells part of their job is telling senescent cells apart from healthy ones were just helping them do their job, he said.

Its still an open question. But clinical trials to answer it could be underway by the end of next year. Bhushans initial discoveries are now being developed by a biotech startup called Deciduous Therapeutics, which he co-founded in 2018. Deciduous is backed by 8VC, CRV, and Laura Demings Longevity Fund, and has until now, been operating in stealth. CEO and co-founder Robin Mansukhani told STAT that the company has been focusing on developing compounds that can best stimulate human iNKTs, whose receptors are structurally a bit different from those of a mouse. He expects Deciduous to file its first investigational new drug application to start human testing within the next 18 months, likely for a metabolic disease or fibrotic lung disorder.

Investors pumped the brakes on senolytics after one of the biggest and brightest stars of the nascent sector and another Longevity Fund portfolio company, Unity Biotechnology, announced last August that its lead drug candidate had failed to reduce knee pain in patients with osteoarthritis. The experimental drug was immediately and unceremoniously dumped, along with nearly one-third of Unitys staff.

But despite the recent slowdown, Mansukhani remains optimistic. The issue in the field has always been what is the actual immune system process behind senescence clearing?he said. And I feel like weve uncovered that.

Mayos Kirkland cautions that deciphering one chapter of the immune system users manual isnt likely to be the whole story. Senescence can be caused by lots of things aging, yes, but also obesity, chemotherapy drugs, and radiation. There are about 40 to 50 different things that can push a cell into a death spiral, said Kirkland. That makes it really hard to define what a senescent cell is, because its molecular makeup depends on how its senescence was induced.

But the good news, according to Kirkland, is that all the fundamental aging processes mitochondria powering down, oxygen radicals disfiguring DNA, rampant inflammation, the spiral toward senescence appear to be tightly interlinked. Its looking increasingly like if you hit one part of this network of things going on, you affect all the rest, and usually in a positive way, he said.

Kirkland, together with his team at Mayo, have had some success with a cocktail of dasatinib and quercetin. In 2019, they reported positive results from a Phase 1 pilot study of nine diabetic kidney disease patients senescent cells were reduced. A Phase 2 study is now underway. And his team has several more trials for serious conditions, including osteoporosis and Alzheimers disease, in the pipeline. Kirkland serves as a scientific adviser to a new senolytics company called NRTK Biosciences that has yet to receive funding and anti-aging supplement company Elysium Health.

But the real question for the future, said Kirkland, is which interventions can you combine to get an additive, synergistic effect? Something that actually alleviates not just one disease of aging, but many, or even all of them? Figuring out how immune cells interplay with senescence is going to be the start of looking for those combinations.

Thats whats next for Bhushans lab a painstaking process of deleting different antigen-displaying peptides across dozens of types of immune cells, and mapping out the almost infinitely complex network of interactions brewing in the toxic stew surrounding senescent cells.

We know we only have part of the story, Bhushan said. We know we can fix whatever is going wrong with iNKTs, but we still dont know exactly what that is.

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Reawakened immune cells attack cells tied to diseases of aging - STAT - STAT