Category Archives: Anti-Aging Medicine

Some billionaires are trying to conquer space. Others maintain a more earthbound ambition: to outsmart the Grim Reaper.

And deep-pocketed age-hackers are putting their money where their mouths are. Larry Ellison chairman of the software giant Oracle has donated around $500,000 to anti-aging research. Google co-founder Larry Page helped fund Calico, a lab that describes itself as wanting to better understand the biology that controls aging and life span.

Meanwhile, Peter Thiel the entrepreneur behind PayPal was an early investor in Unity Biotechnology, which is devising therapeutics to delay aging-related diseases at the cellular level. (The company raised $116 million in 2016.)

Nir Barzilai, author of Age Later and director of the Institute for Aging Research at Albert Einstein College of Medicine, describes some of these high-profile anti-agers as immortalists: People who believe death is an option, rather than an eventuality given the right hacks.

Because of that, we expect $4.5 billion to be invested [in life- and health-extending science] this year alone, he told The Post.

Despite being a player in this world, Barzilai takes a more measured approach: Living forever might not be in the cards, but we are working on specific problems that will increase life span and healthspan, or how long one stays healthy for.

Nevertheless, ardent believers buy into the concept of living upwards of 5,000 years or even, as Thiel told the New Yorker, forever. Its the kind of thinking that gets money funneled into experiments such as the one conducted by researchers at the National Academy of Medicines Healthy Longevity Global Grand Challenge, in which an old mouse and a young one were surgically connected so that they shared blood, resulting in the oldster becoming youthful.

A similar study, done by researchers at Stanford University and University of California San Francisco, showed a turnaround in cognitive aging and better memory in elder mice that were injected with the plasma of younger ones.

If the planets richest men have their way, prolonging life and curtailing deadly diseases may be no more pie-in-the-sky than home computers were in the 1940s.

And some of the worlds top scientists are working right alongside them.

David Sinclair, author of Lifespan, who heads up labs at Harvard Medical School and University of New South Wales in Australia is a diehard believer in extended life spans. By the turn of the next century, a person who is 122 on the day of his or her death may be said to have lived a full, though not particularly long, life, he wrote in his book. Living until 150 may not be out of reach.

In the not-too-distant future, he predicts, age-reversing injections, laced with a small number of reprogramming genes, will be administered to people who turn 30 and be made to kick in 15 years later: Gray hair would disappear. Wounds would heal faster. Wrinkles would fade . . . Like Benjamin Button, you will feel 35 again, then 30, then 25.

For now, though, Sinclair is focused on a potential aging culprit: the epigenome, which is made up of chemical compounds and proteins that can attach to DNA and direct it. As he explained to Popular Mechanics, the epigenome turns genes on and off, but it loses information as we age. (Sinclair likens the degeneration to a scratch on a CD.) He said, I think it stops cells from reading the right genes.

While working to fix that life-altering glitch, Sinclair tries to stave off his own aging with more accessible tricks. He takes a regimen of vitamins (including D and K, the latter believed to keep bones healthy) and medications such as Metformin, which is clinically prescribed for Type 2 diabetes, but also appears to reduce incidents of other aging-related diseases.

He also fasts on a daily basis by skipping breakfast and having a late lunch, which, he said on a YouTube video, has been shown to extend [the] life span of everything from yeast cells . . . to monkeys exercises and eschews red meat.

Barzilai and Sinclair who are friends are simpatico in their beliefs about the epigenome, exercise and diet. But Barzilai said he can give or take the vitamins, describing them as Good for the economy; [but] they do not stop aging and are mostly helpful if you have a deficiency.

He believes that aging drives diseases. If you stop aging, you stop diseases. In other words, Barzilai said, The mechanisms that target aging are the same mechanisms that extend healthspan and extend life span.

Along that line, he, too, has been doggedly investigating the diabetes medicine Metformin as a source of healthfulness. Describing the pills as safe and generic and cheap, he personally takes them, and is currently leading a study called TAME: Targeting Aging with Metformin. Barzilai believes that the drug, which helps the body to use insulin more effectively, also slows other hallmarks of aging (including the decline of immunity). In studies with animals, we are using it to [lower incidents of] Alzheimers, cancer, cardiovascular disease and diabetes 2. [Studies] show that old people using Metformin had one-third the mortality from COVID.

The study will take another 4 to 6 years to complete, but Barzilai said that those interested in taking it for off-label purposes can ask their doctors.

Barzilai, a newly minted senior citizen at 65, has slightly more accessible goals than the immortality-chasing billionaires who finance research like his. Im sticking to the idea of being healthy until 85, he said.

If you tell me I will live for 12 billion years, Ill wonder how many catastrophes I will have to endure. I dont want that. I want to extend health. Longevity is a side effect.

Original post:
Inside the billionaire-funded fight to conquer aging and cheat death - New York Post

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Another buzzy name is taking over the health and wellness industry, infiltrating sparkling drinks, superfood supplements, and even skincare: adaptogens. Despite their recent popularity, use of the Ayurvedic herbs and fungi is nothing new; people have relied on the ancient medicine for thousands of years to treat a range of concerns, such as managing stress levels and combating inflammation. While ingesting adaptogens can bring numerous benefits to the body, applying them topically to the skin has been proven to do wonders, too, minimizing dryness, fine lines and wrinkles, eczema, and irritation like no other.

According to shoppers, the Youth to the People Adaptogen Deep Moisture Cream is one of the best recent skincare remedies to come from adaptogenic beauty. Reviewers have called it a "magical elixir" for achieving beautiful skin, with some noticing significant results after just a week of use. Those with ultra-sensitive and dry skin feel as though they've found their "holy grail moisturizer," with one reviewer sharing that it keeps their skin feeling supple, "even in the Colorado dry climate."

The fragrance-free, vegan formula has a bountiful list of ingredients, including a proprietary adaptogenic blend of ashwagandha, rhodiola, and reishi. The trio brings plenty of antioxidants and amino acids to the complexion, working to counteract signs of aging and fatigue, while helping your skin react better to stress and environmental aggressors. Alongside the adaptogens, squalane, jojoba oil, and shea butter surge the skin with a heavy dose of hydration, and according to reviewers, keep the skin feeling moisturized "all day long" without any greasy residue. Even better, you'll find no dimethicone, parabens, or phthalates listed on the recyclable, 2-ounce glass jar.

"I've developed very sensitive skin over the last few years and I've tried everything to get it feeling fully moisturized with no success," shared one shopper. "Most hypoallergenic moisturizers aren't moisturizing enough for me. This is wonderful. I just wish it came in a bigger size. It's hard for me to avoid going through it too fast."

"My skin has improved immensely since I started Youth to the People," said another. "I barely wear foundation anymore and there is a visible difference; I regularly get compliments about my skin being clearer and brighter. It changed my skin in under two weeks of consistent use. I LOVE IT!!!"

Youth to the People recommends applying the cream to clean skin morning and night for the best results. Snag the anti-aging hero taking over regimens everywhere for $58 on the brands website.

Originally posted here:
Youth to the People's Adaptogen Anti-Aging Cream Has Shoppers Hooked - InStyle

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Anti-Aging Medicine Market Trends Analysis Report By Product, Competitive Landscape And Growth Forecast 2021-2027 The Manomet Current - The Manomet...

Recently I posed a question about a patient, drawn from my own practice: Is It the Right Time to Deprescribe This Frail Patient's Metformin?

My patient was an 81-year-old woman with type 2 diabetes of 20 years' duration, chronic kidney disease, obesity, and mild dementia. Her family hoped to reduce the number of medications she was taking, one of which was metformin. I decided that we could accept a less stringent A1c goal, so I discontinued her metformin and monitored her glycemic control.

Thank you for the lively discussion and strong ideas regarding the care of this patient. In a case without a clear correct response to the options (continue metformin, discontinue metformin, reduce the dose, or switch to an SGLT2 inhibitor), readers' opinions were decidedly split on the best course of action.

The most common solution was a compromise: Continue metformin, but with the once-daily, extended-release form. This would reduce her pill count and the burden on the patient and her family for medication adherence. Some evidence suggests that this intervention can be effective. In a meta-analysis of 51 studies, there was a gradual reduction in medication use with each additional daily dose. The difference in medication use comparing once-daily and twice-daily regimens was -6.7%. This result was statistically significant but not highly impactful clinically. However, there was a 13.1% difference favoring once-daily dosing vs twice-daily dosing in terms of overall regimen adherence.

Another lesson I take from the advice to reduce her dosing frequency is to think outside the managed care formulary. Our managed care plans for Medicaid and Medicare do not cover extended-release metformin, so I did not even consider this option.

A couple of readers mentioned another possible reason to continue metformin for this patient: as a potential anti-aging medication. There is evidence that metformin has activity on the 5'-AMP-activated protein kinase pathway, where it can help reduce inflammation and cellular stress. Metformin supplementation in middle-aged mice was associated with a 5.8% increase in lifespan. The UK Prospective Diabetes Study found a cardiovascular benefit associated with long-term metformin use among adults with diabetes, but meta-analyses have failed to find a benefit associated with cancer for metformin. Overall, there is not enough current evidence to recommend metformin as an anti-aging medicine, but two trials are underway evaluating the effects of metformin among adults without diabetes.

Finally, it is worth considering the point of deprescribing. Patients should not feel abandoned or that they are not worthy of certain treatments. The values and preferences of patients and their supporters are highly important in the decision to discontinue chronic medications. But it is the clinician's duty to bear these things in mind:

Polypharmacy is common among older adults, and it is associated with a higher risk for gait decline and falls. This is true even after adjusting for confounding by indication.

There are many chronic medications which are unproven among older adults. More research is necessary in this area, particularly as the population as a whole ages.

There was more than one correct answer to this clinical scenario. However, a dogmatic approach that is not patient- (and family-) centered can do more than damage the relationship between clinician and patient. It can result in more loss to follow-up, less preventive care, and higher rates of morbidity and mortality.

See the rest here:
Discontinuing Metformin: The Crowdsourced View - Medscape

The coronavirus pandemic has dominated the headlines and our daily lives for more than a year. Medical News Today has covered this fast-moving, complex story with live updates on the latest news, interviews with experts, and an ongoing investigation into the deep racial disparities that COVID-19 has helped unmask.

However, this has not stopped us from publishing hundreds of fascinating stories on a myriad of other topics.

This week, we begin with news of whats exciting researchers working on dementia. We spoke to six experts who discuss the latest work to improve the quality of life of people with the condition, find new targets for treatment, and monitor the risk of dementia in former sports players.

We also offer the latest in our Medical Myths series, this time tackling 11 common misconceptions about migraine, and coverage of a study revealing the hazards of wearing fashionably pointy footwear in Medieval England.

Next, we delve into how the biology of naked mole rats allows them to resist aging and cancer and live for decades. Its all in their genes, of course. Next up is an examination of the multifaceted role of omega-3 fatty acids in cancer and depression. Finally, we close out the week by exploring the benefits of going for a walk after eating its good news for those who make the effort.

We highlight this research below, along with several other recent stories that you may have missed amid all the COVID-19 fervor.

How far are we from finding effective treatments for dementia? MNT quizzed six experts about the research they find most exciting and shared their responses as part of a Special Feature.

One fertile area of research is how we might improve quality of life for people with dementia. Maintaining familiar routines, sensations, and personal possessions appears to be important. We also report on the recent discovery that decreased blood flow to the brain can precede cognitive decline by years and could actually cause dementia. This spurred research into the precise role of blood supply in neurodegenerative diseases, and the reason why a failing memory may be one of the earliest signs of dementia.

Learn more about the latest dementia research.

June is National Migraine and Headache Awareness Month, so this weeks edition of Medical Myths tackles some misconceptions about migraine.

How serious are migraine headaches or episodes? Are they simply a kind of headache? Do special migraine diets help? What about supplements? Does caffeine cause migraine? We tackled each question in turn with the help of three experts. We also look at how prevalent the condition is in the United States and worldwide.

Though there is no cure for migraine yet, research into the condition is ongoing, and new treatment options, including smartphone apps, are emerging.

Learn more about migraine.

This week, we reported on a claim that a penchant for pointy shoes among the well-heeled of Medieval England may have spurred an increase in bunions.

Archaeologists at the University of Cambridge in the United Kingdom examined skeletons dating from the Middle Ages. They found evidence that bunions were significantly more common in the 14th15th centuries than in the 11th13th centuries. They were also more prevalent in affluent areas.

For more on this fascinating insight into life in Medieval England, and the health problems affecting the most affluent and privileged people of the time, jump to the article via the link below.

Learn more.

Naked mole rats are of great interest to scientists, as they live for over 30 years and are apparently immune to aging. Very few, if any, of these rodents have been found to have cancer, while theyre also highly resistant to some types of pain. They can also survive for up to 18 minutes without oxygen, making them extraordinarily resilient little creatures. As such, researchers are working hard to unravel the secrets of their anti-aging abilities.

A recent study, covered by MNT this week, focuses on the adaptations that protect the genome in naked mole rats. It appears that they are not only able to correct mutations in their DNA, they also benefit from an extra copy of a gene that protects their DNA from damage in the first place.

Learn more about naked mole rats.

One of our most popular articles this week reported on a study revealing how the brains of people with Alzheimers disease may contain metal contaminants. Researchers were surprised to discover highly reactive particles of elemental iron and copper in postmortem brain samples. Furthermore, these metals appeared to be stabilized within the beta-amyloid plaques, a hallmark of the disease.

Before this discovery, scientists had only identified these elemental metals in microorganisms, viruses, and plants. Their presence in human brains could ultimately lead to new treatments that target metals and also aid diagnosis. Click the link below to learn more about how researchers were able to detect metal particles and rule out contamination of their samples.

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Can consuming certain foods or nutrients reduce the risk of developing cancer? One growing area of cancer treatment research is the therapeutic potential of dietary interventions.

Previous studies in mice suggest that omega-3 fatty acids may be effective as an antitumor treatment. Now, new research has identified a possible mechanism that explains this. It appears that omega-3 fatty acids encourage tumor cell death via a process called ferroptosis, but this was not seen with other fatty acids.

This finding supports the case for targeted dietary intervention with omega-3s, though more research is now needed to determine whether the same effect applies to humans.

Learn more.

We stay with omega-3s in our next article, this time exploring their role in depression. Researchers in the United Kingdom have discovered that high doses of these fatty acids may help relieve symptoms of this condition. Their anti-inflammatory effect appears to decrease the rate of cell death in a region of the brain called the hippocampus.

This may partly explain the observation that people who eat a diet rich in fish and seafood have a lower risk of depression, as such foods are high in omega-3 fatty acids.

Learn more.

Another of this weeks articles examined the effect of everyday stress on depression. The brains of people without this condition are better at adapting to elevated stress, and this can be observed in changes to the medial prefrontal cortex. An inability to accommodate in this way may lead to depression.

To discover how these brain changes were identified, the studys limitations, and how its findings might apply to treating depression, click below.

Learn more.

This week, our editors published this important article on the consequences of gender bias in medicine, focusing on misdiagnosis, delays in treatment, and how it may risk avoidable deaths.

With examples including chronic pain, bleeding disorders, autoimmune conditions, mental health, COVID-19, and heart disease, we look at the causes of gender bias, its roots in sexism, and what can be done to counter its pernicious effect on people of all genders. Its clear that gender bias in diagnosis, medical research, and treatment causes harm and needs to be eliminated from medicine.

Learn more.

Finally, this week, we look at an activity enjoyed by millions after a meal. Walking has many benefits, but does going for a post-dinner stroll have any downsides? We look at the evidence and conclude that on the whole, it is a healthy activity, but you may want to wait a little while after a substantial meal.

To discover all the mental and physical benefits of heading out after tucking in, follow the link below.

Learn more.

We hope this weeks Recovery Room has provided a taste of the stories that MNT covers. We will be back with a new selection next week.

We publish hundreds of new stories and features every month. Here are some upcoming articles that may pique our readers interest:

Continue reading here:
The Recovery Room: News beyond the pandemic June 25 - Medical News Today

Whether its wheatgrass shots or green juices, sipping verdant drinks in hopes of reaping health benefits is far from a new health trend. Now, though, another green beverage called chlorophyll water has stepped onto the scene this time, by way of TikTok.

Chlorophyll water is made out of water and chlorophyll drops, and influencers claim it can make your skin glow, trim your waistline, and boost your energy.

We consulted health experts to get the lowdown on this buzzy drink and whether you should try it.

RELATED: Can Lettuce Water Actually Help You Sleep?

Chlorophyll is a constituent that exists in plants and is a pigment that gives them their green color, says Gary Soffer, MD, integrative medicine physician at Yale Medicine in New Haven, Connecticut. As you might remember from eighth grade science, Dr. Soffer says, [chlorophyll] is an essential part of photosynthesis, the process that allows plants to derive energy from light. Natural sources of chlorophyll include green leafy veggies such as spinach and kale, herbs, and sprouts, he adds.

Chlorophyll drops, on the other hand, arent made of 100 percent of chlorophyll but instead contain chlorophyllin, a water-soluble version of chlorophyll that combines sodium and copper salts with chlorophyll. The claim is that compared with chlorophyll, chlorophyllin is more absorbable by the body, says Keri Gans, RDN, a nutrition consultant in New York City and author of The Small Change Diet. Soffer adds that it is often derived from alfalfa (Medicago sativa), silkworm droppings, and algae.

Yet none of these qualities make chlorophyll drops more beneficial than natural sources of chlorophyll that is, whole, green foods.

RELATED:11 Green Foods (and 1 Drink) That Are Good for You

Weight loss, cancer prevention, anti-aging, and wound healing are just some of the perks that influencers are crediting to chlorophyll water. Heres what you need to know about the most popular claims circulating on social media.

Influencer @lenamaiah has shared a video claiming that drinking chlorophyll water cleared up her rosacea, adding that it reduces inflammation, is full of vitamins A and C (which helps with skin regeneration), and helps blood carry more oxygen to the skin.

What Research SuggestsGans confirms that there are anecdotal reports chlorophyll can help with skin issues, including rosacea, but current scientific evidence is lacking.

User @Han.tidote shared a video on TikTok that has been viewed over 1.9 million times, claiming that chlorophyll water can remove odor from your sweat. Her favorite benefit? When I'm at the gym I literally don't even smell bad. I just sweat, @Han.tidote exclaimed.

What Research Suggests In 1953 (yes, nearly 70 years ago) F. Howard Wescott conducted research published in JAMA claiming that chlorophyll could stave off bad breath and body odor. While there have been a few small studies and clinical trials supporting this theory in the decades since, experts, including Gans and Soffer, maintain that there is not yet enough persuasive scientific evidence to recommend using chlorophyll for this intention.

RELATED: What Is Dry Scooping? What to Know About the TikTok Trend

The user @Han.tidote added that chlorophyll water is basically like coffee, and that your energy is through the roof after you drink it.

What Research Suggests Gans points out that any evidence supporting chlorophyll as an energy booster is very limited. One study from China published in March 2019 in Evidence-Based Complementary and Alternative Medicine determined that chlorophyll tablets with a similar molecular structure to hemoglobin may improve anemia symptoms, which includes fatigue. The specific tablets were called shengxuening, which are extracted from the excrement of the silkworm and are used as a component in traditional Chinese medicine herbal therapy.

Although the study was a randomized clinical trial in about 2,000 people factors that make the study model more rigorous than, say, a small observational study researchers studied these effects in a specific patient population and using this tablet formulation, so the results arent necessarily applicable to a general population without anemia. More research studies would be needed before recommending chlorophyl to reduce fatigue.

My stomach has never been flatter, TikTok user @katsofia444 captioned on a clip of herself in a crop top sipping on the green water.

What Research Suggests One small, previous study offered limited evidence that subjects who consumed green plant membranes, similar to chlorphyllin, for three months did experience more weight loss than those who didnt take the supplement,claiming that it reduced cravings for sweets and chocolates. But this study has a weak spot: Only 40 subjects were involved in the study. Therefore, more research is needed.

Another claim making the rounds on social media this time, Instagram is that drinking chlorophyll water can boost immunity. Instagram user @allys_eats shares that amongst its many benefits, drinking the green concoction supports immune function.

What Research Suggests Antioxidants can help fight cellular damage from free radicals, improving immunity and warding off a variety of diseases, including cancer, according to the National Institutes of Health (NIH)National Cancer Institute. There are limited rigorous studies supporting the antioxidant properties of chlorophyllin. The majority are either lab based or animal studies, and not done in human studies.

RELATED: Drinking More Tea Especially Green May Help You Live Longer

Instagram user @healthy.and.wellthy says chlorophyll is effective at fighting certain types of cancer.

What Research Suggests There is currently no high-quality scientific evidence that chlorophyll supplements can treat, prevent, or fight certain types of cancer. There is very limited scientific evidence that chlorophyll can help reduce your bodys absorption of aflatoxin B, a toxin found in plant products (such as peanuts) or by consuming meat or dairy products from animals linked to liver cancer, per the NIH.

Instagram user @allys_eats shares added that chlorophyll water Detoxs your body by binding and removing toxins and heavy metals, improves gut health by keeping a balance of healthy bacteria in the gut and aids with optimal digestion.

What Research Suggests A past review debunked the majority of claims made about the potential benefits of chlorophyll, noting that there is no substantial evidence that it can help with detoxification, or digestion.

RELATED: 14 Healthy Salad Greens Ranked From Best to Worst

Most of the claims made on TikTok are anecdotal, meaning that other than the endorsement of individuals on TikTok, there is little scientific evidence that chlorophyll drops can do anything more than turn your water green.

As of now most scientific research showing benefit has been done in lab settings or in animals, Soffer explains. There have been no large scale trials demonstrating its benefit.

That said, if you want to try them, the risk of harm, as reported in studies and other adverse event reporting, is essentially nonexistent. Both Soffer and Gans explain that there arent any known serious health risks of chlorophyll drops. Given that quality of supplement production isnt regulated in the same way that pharmaceutical drugs are, though, there is always some added risk when taking liquid or pill form supplements. Opt for a trustworthy company whose products have undergone testing from third parties such as ConsumerLab.com, U.S. Pharmacopeia (USP), and NSF International.

The fact of the matter, though, is you dont have to invest in a new product to get in on the potential claimed benefits of chlorophyll.

Probably the best way and the most inexpensive way is to simply get your chlorophyll naturally from green vegetables, Gans explains. At the very least, you will be reaping the proven benefits of eating lots of antioxidant-rich green veggies known to have anti-inflammatory properties, which may help to balance immune health, decrease risk for cardiovascular disease, and prevent certain cancers, Gans points out.

One highly cited study, published in the Journal of American Dietetic Association, found that fruit and vegetable consumption was incredibly beneficial for controlling inflammation and oxidative stress, reducing risk for chronic disease.

Soffer suggests green leafy vegetables, herbs, and sprouts if you want to get your chlorophyll fix.

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Chlorophyll Drops on TikTok: Should You Try Them? - Everyday Health