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David Sinclair on Solutions Within Decades – Lifespan.io News

Posted: March 27, 2024 at 2:45 am

In this new interview, David Sinclair, Harvard professor and the author of Lifespan, explains his theory of aging, shares parts of his health routine, and reveals which directions in todays aging research excite him.

In the longevity field, when it comes to name recognition, theres David Sinclair and all the rest. Like in many other areas, this gap in popularity doesnt necessarily reflect the actual professional hierarchy. Dr. Sinclair, a Harvard professor, is undoubtedly a very prominent aging researcher, but he would probably agree (although we didnt ask) that he has many equally worthy colleagues.

Some of Dr. Sinclairs popularity stems from his highly successful Lifespan: Why We Age and Why We Dont Have To, a great entry-level book that did a lot to introduce the science of aging and the ideology of life extension to the public consciousness. Now, a new book is in the works, and it differs from the first one, Dr. Sinclair told us, in that Lifespan is the textbook, Lifespan II is the guidebook. That probably means we can expect some expert wisdom on how every one of us can stay healthier and live longer. Dr. Sinclair maintains an interesting personal routine, which we also asked him about.

Today, Dr. Sinclair is one of the most visible longevity advocates, expertly broadcasting the message of life extension from top-tier platforms such as Joe Rogans and Peter Diamandis podcasts. He carefully chooses his appearances at conferences, where he receives rock star-like attention.

All this does not mean that Dr. Sinclair has completely morphed into a public figure. On the contrary, he and his team at Harvard continue to produce some of the most interesting results in the field, which we have covered extensively. He is one of the pioneers in practical applications for partial cellular reprogramming, having demonstrated that it can regenerate crushed optic nerves in mice and non-human primates.

Like many high-profile researchers, Dr. Sinclair has his pet theory of aging. The current ruling paradigm is the Hallmarks of Aging, the processes that include genomic instability and telomere attrition. Together, they are responsible for the phenotype of aging that we are all familiar with. Scientists know that many if not all these processes are interconnected, but is there an actual hierarchy?

Dr. Sinclairs answer to that is yes. According to his Information Theory of Aging, cells health and function depend heavily on epigenetic information, a set of instructions in the form of slight chemical alterations to DNA molecules that governs the expression of genes and other elements of our DNA, such as retrotransposons. This is what tells cells into which cell type they should differentiate and how they should perform this types duties.

With time, various stressors throw our epigenome into disarray. Imagine pages of a manual being accidentally torn out, having coffee spilt over them, and so on. Epigenetic alterations are indeed one of the Hallmarks of Aging, and their contribution to aging is widely acknowledged. However, Dr. Sinclair takes it one step further.

First, those changes, he says, are responsible for a very significant part of aging that is, they are high upstream and influence many or all other hallmarks. Second, he postulates that there is a copy of the manual that can be used to restore the epigenome to its youthful state. We can see hints to this in cellular reprogramming, where cells can be either thrown back to their pluripotent (undifferentiated) state and almost completely rejuvenated, or partially reprogrammed and partially rejuvenated.

If we can find that pristine backup copy of cellular epigenetic information and learn how to use it, the possibilities are endless. A recent study by Sinclair et al. presents findings in support of the theory. Its not conclusive evidence yet, but definitely hope-inspiring. For more on this and other topics, we turned to David himself, and he kindly agreed to answer a few questions.

According to the Information Theory of Aging, epigenetic changes that disrupt gene expression patterns as we age are driven by cell stress and damage, such as DNA breaks. This process causes cells to lose their function and identity, to become exdifferentiated, and this may be a cause of many of the changes seen during aging, including some major age-related diseases.

Its not yet known how potent the effects of in vivo epigenetic reprogramming will be. We know it can improve the function of the eye to cure blindness in mice and monkeys and even improve the function of the brain, but whether it can fix the many problems that occur with age in the human body is not known.

The hypothesis predicts that there is chemical information in cells that encodes the youthful structure of the epigenome so that it can be reset, and gene expression can be restored to an earlier age. We know that it is possible to reset gene expression. We dont yet know for sure how and where this information is stored, but we are working hard to find these answers.

The hypothesis is that the backup copy stores the cells youthful chromatin structure that controls which RNAs and proteins are expressed. Resetting these structures allows the cell to regain its differentiated state and its youthful functions.

The hypothesis is that rejuvenation is important for germ cells and embryos to maintain youth. We speculate the putative backup copy is also important for the rebuilding of damaged organs and tissues. Many species can regrow entire body parts, from limbs to heads. With the exception of our livers, which can regrow after damage or surgery, we humans have largely lost the ability to regrow organs and limbs.

Species that live a long time are known to have a more stable epigenome than those that live shorter. We suspect this might be because they are better at preventing and repairing DNA damage, which we have shown can accelerate age-related changes.

Antagonistic pleiotropy is a process that is advantageous when organisms are young, but they cause problems later in life, when the force of natural selection is so weak they continue to exist in the germline. The processes that disrupt the epigenome seem to be useful in young organisms because they recruit chromatin factors to sites of broken DNA and increase DNA repair and stabilize chromosomes. We first saw this in yeast cells in Lenny Guarentes lab in the late 1990s, then later in mammals, in my own lab in the 2000s. The problem is that the recruitment doesnt reset fully, and chromatin regulators lose their place on the genome, causing exdifferentiation of cells. In 2007, we called this the Relocalization of Chromatin Hypothesis of Aging or RCM, and it was later incorporated into the Information Theory of Aging.

We have not seen any evidence for this claim after a decade of studying the system, the results of which are in the paper showing cells do not experience cytotoxicity. Our detailed response to the claim has been published in Cell.

We have a long way to go. Most people havent heard of aging research or the results that are being produced. Most doctors are also unaware of the advances in the field.

I think our biggest bottleneck is having access to old mice that we can study. One solution would be to have a source of them for all researchers.

Saying there is no known upper limit doesnt mean we can live for decades or centuries longer. I dont know of any technology that would allow Longevity Escape Velocity currently, but I also know saying something is impossible is a dangerous thing in this time of human history.

Im excited about senolytics, epigenetic reprogramming, and the use of AI in healthcare.

I have hopes we will be able to rejuvenate people in the next few decades. If all goes well, Life Biosciences will be testing vision restoration in humans in 2025.

Im not simply relying on anecdotes. Changing my lifestyle has resulted in changes to my blood biomarkers that are consistent to long-term health. Vegan diets are considered some of the healthiest of all, and this is backed by multiple human studies. Skipping meals so that my eating window is shorter, which is what I try to do, is backed by evidence indicating that it improves metabolic health and lowers inflammatory markers, among other benefits.

We know their safety profile. Metformin has been in tens of millions of people. Metformin and low-dose rapamycin appear to be relatively safe. Whether they are effective at slowing aging and safe in combination is not yet known.

After this interview was taken, David Sinclair has stepped down as President of the Academy for Health & Lifespan Research, as announced on X by another co-founder, Nir Barzilai.

To do this, we need your support. Your charitable contribution tranforms into rejuvenation research, news, shows, and more. Will you help?

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David Sinclair on Solutions Within Decades - Lifespan.io News

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The Transgender Movement Is Morphing Into The Transhumanist Movement And The Results Are Horrific – The Daily Wire

Posted: March 27, 2024 at 2:45 am

Its been more than two weeks since the WPATH files demonstrated very clearly that so-called transgender medicine is the single most unethical and barbaric practice that the medical industry has ever endorsed.

Its a coordinated effort to permanently destroy the bodies of thousands of young children. The doctors who are involved in this butchery understand very well that children cannot consent to permanent sterilization and amputation. Theyve said it on tape, as the WPATH files prove, and yet, despite these revelations, no major hospital has announced that theyre cutting ties with WPATH. In fact, they havent responded to the WPATH files at all.

Instead, as of today, hospitals like UCLA and Massachusetts General proudly declare on their websites that they carefully follow WPATHs so-called standards of care as they castrate their underage patients.

What this means is that the medical industry is all-in on WPATH. Hospitals and medical associations arent going to disassociate with these quacks, at least not until theyre forced to.

They simply dont care about the fact that theyre ruining the lives of children who cant provide informed consent. In practical terms, for now, this means that some of the most disturbed and ideologically driven deviants on the planet the experts at WPATH will continue to write the book on so-called trans medicine. They have free rein.

So its worth taking a closer look at who exactly these experts are, since no one else in the medical establishment is interested in doing so. As Genspect highlighted this week, one of these experts is a New York psychotherapist using the name Laura Jacobs. On his website, Jacobs proudly lists his affiliation with WPATH, including his work on formulating WPATHs standards of care.

Reduxx looked further into Laura Jacobs background. They found that he quote, influenced the development of transgender health guidelines regarding gender dysphoria in adolescents [and] previously contributed a chapter to an anthology in which he promotes BDSM practices, including age play and genital torture.

Apparently, this is the kind of resume that qualifies a man to become a WPATH-certified expert, and to come up with the highly permissive criteria that doctors use in order to castrate children all over the country.

And yet, if you look a little closer, this guy is somehow even weirder and more unsettling than his bio would suggest.

This is a video that was found by a researcher named Jonny Bell. Its from a TedX talk that Jacobs delivered a couple of years ago. Watch as Laura Jacobs begins by explaining his own gender identity:

Theres more to this clip, but its important to stop there and highlight the complete and total incoherence of what you just heard. WPATH-certified medical professional Laura Jacobs says he likes to play with gender, which means hes gender-queer. He says he feels female and male. He also feels both and neither, at the same time. He says that various labels feel equally authentic and inauthentic.

Its hard to think of a better illustration of the way trans activists can string sentences together that mean absolutely nothing. Its a characteristic that every single trans activist has in common, without fail.

They advance their ideas not by convincing anyone, but by confusing them.

Authenticity is the opposite of inauthenticity. Male is the opposite of female. If you think something can be two mutually incompatible things at the same exact time, then you are extremely confused on every conceivable level.

This is no different from saying that someone can be a bachelor and married at the same time, or that a square can be a square while equally being a circle. Its the definition of nonsense. And this is how gender ideology is promoted. Not with arguments or explanations, but with an avalanche of pure, unbridled nonsense, that, the ideologues hope, will distract and confuse you so much that you throw up your hands and agree with whatever crap theyre spewing. And here Im assuming that Jacobs knows hes saying a bunch of nonsensical drivel. If he thinks that it actually makes sense then instead of working on the medical standards that every major hospital follows, these 30 seconds are strong evidence that Laura Jacobs should probably seek some help himself.

Although what comes next is even better evidence of that last point.

Laura Jacobs doesnt stop there. Narcissists never admit defeat, even when their own arguments are self-defeating. Instead, Jacob launches into an extremely creepy transhumanist monologue. As you watch this, keep in mind, again, that this is a representative for WPATH, which every major medical organization and hospital currently pretends is a legitimate authority. Watch:

Do we have to stick to penis & vagina norms? asks Jacobs. Can we have genitalia that look like flowers or abstract sculpture? Can we have multiple? Can they be interchangeable? And what about other areas of the body?

This is body-horror at its most deranged. If a filmmaker made a horror movie where people were walking around with genitals that looks like abstract sculptures, Id think that filmmaker was a deranged creep. But Jacobs wants to do this in real life.

Once you get past the raw, human disgust that you feel listening to someone talk like this, you begin to recognize that it was inevitable that wed get to this point. Transgenderism the belief that people can change their gender has always had a lot in common with transhumanism, which involves the use of technology to alter the human condition. It was unavoidable that the two ideologies would converge, as they are really the same ideology dimensions of the same basic idea. Both transgenderism and transhumanism are grounded in a rejection of both the classical and Christian traditions of human nature. They want to make human beings gods over themselves, over their own nature.

Transgenderism and transhumanism have more in common with Machiavelli, who taught that the only truth is effectual truth meaning, what you can control. There is no transcendent authority in this understanding. Humans are their own gods. That is the essence of transgenderism, and now its coming to the forefront. More and more, people identifying as transgender are admitting that theyre not really receiving medical care or anything like that. That was always a lie one that WPATH was founded in order to spread. Now were seeing so-called transgender individuals coming right out and admitting that their real goal is to embrace transhumanism. They dont just want to change genders; they want to redesign their entire body. They dont want to resemble men or women; they want to carve up their body parts into starfish and flowers.

Its not just one WPATH quack whos pushing this, as disturbing as that would be. The child psychologist Elliot Kaminetzky recently noted that the popular website Healthline recommends that visitors talk to a surgeon if theyre interested in splitting their penis in half, or creating other various designs out of their genitalia. There are various diagrams on Heathlines website that are too graphic to share. This is supposedly a leading website that people turn to for medical information. Like WPATH, theyre trying to normalize genital mutilation, not in the name of transgenderism, but in the name of transhumanism.

Spend some time on social media, and youll find this idea is catching on. Heres a few clips from an upcoming documentary on this topic. Listen to how young people are talking about transgenderism and how they perceive themselves:

There was always a contradiction between transgenderism and Christianity. And now a lot of trans activists are making that contradiction explicit. Theyre denying that man was made in Gods likeness, which is obviously a biblical teaching, and instead, theyre equating man with various inert objects, like wheat and grapes. Which means the whole pretense of transgender medicine is long gone. Were entering into blasphemous, cultish territory here, and theyre basically admitting it. And again, this is a rapidly growing segment of the so-called trans community thats talking like this.

Go on YouTube, and youll find an assortment of demented videos about so-called trans people who think theyve transformed into lizards and dragons. And they have millions of views. Here are just two of them:

The upshot of all this insanity, again, is that the veneer of transgenderism as some kind of serious medical discipline is fading, and its fading very quickly. Weve seen how trans activists claim to be preoccupied with gender-affirming care and freedom, but in many cases, its really a trojan horse for the weirdest and most unhinged excesses of transhumanism.

And make no mistake about it top hospitals in the country endorse this. Until they disavow WPATH and the freak shows like Laura Jacobs who work with them, then theres really no other conclusion we can draw. Increasingly, transgenderism is explicitly about mutilation and body modification in order to achieve some sort of godlike status. And its very clear that these ghouls will sacrifice many more children on their quest for divinity, unless and until theyre finally destroyed for good.

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The Transgender Movement Is Morphing Into The Transhumanist Movement And The Results Are Horrific - The Daily Wire

Recommendation and review posted by G. Smith

Ep. 1331 – The Transgender Movement Is Morphing Into The Transhumanist Movement And The Results Are Horrific – The Daily Wire

Posted: March 27, 2024 at 2:45 am

The Matt Walsh ShowMar 22, 2024

Today on the Matt Walsh Show, a WPATH-certified medical professional suggests that "gender confirmation surgery" should include making "creative genitals" that don't resemble anything that belongs on the human body. This is the kind of horror that was always inevitable, as the transgender movement rapidly becomes the transhumanist movement. Also, rowdy mobs of illegals are now forcibly pushing through the border. The family of the teenage girl who knocked her classmate unconscious and slammed her head into the pavement now say that the attacker is the real victim in the case. And Drew Barrymore declares that after three divorces she feels "totally liberated."

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Ep. 1331 - The Transgender Movement Is Morphing Into The Transhumanist Movement And The Results Are Horrific - The Daily Wire

Recommendation and review posted by G. Smith

Nilam Resources flagged ‘buyer beware’ as shares pump over Bitcoin plans – Cointelegraph

Posted: March 27, 2024 at 2:45 am

Nilam Resources, a micro-cap company that touted plans this week to acquire $1.7 billion worth of Bitcoin (BTC), has been flagged as a public interest concern amid a meteoric 1,500% share price surge on Tuesday, March 26.

OTC Markets Group, the firm that runs OTC Pink, a platform for over-the-counter stock trading, currently labels Nilam Resources (NILA) as Caveat Emptor a designation it hands downto companies it deems worthy of buyer beware.

In a glossary page explaining the labels, OTC Markets explained that this public interest concern may stem from a spam campaign, questionable stock promotion, any known investigation of the company, regulatory suspensions, or any other disruptive corporate actions.

The OTC listing for NILA also shows it has been deemed a Shell Risk a label given to companies it thinks is likely a shell company based on its annual financial data and other income-related metrics.

On March 25, Nilam Resources, an investment holding company, announced it had entered into a Letter of Intent to acquire a company that plans to hold 24,800 Bitcoin.

Nilam Resources claimed the deal had been months in the making. It plans to issue a newly authorized preferred stock in exchange for the Bitcoin, which will be at a discounted rate relative to current market prices.

A day later, its share prices soared, reaching a new all-time high of 33 cents, up 1,700% from 1.8 cents last week. The companys current market cap currently stands at $280 million, according to OTCMarkets.

However, many crypto-natives arent convinced the firm will be able to follow through with its ambitious plan, with some suggesting the announcement is some kind of marketing stunt.

Bitcoin analyst and Adamant Researcheditor Tuur Demeester said he removed his initial tweet sharing Nilams announcement on X after a commenter pointed out that its indeed a stunt from a dying penny stock.

Quinten Francois, a crypto YouTuber and co-founder of Web3 company WhereAt Social also accused the filing of being a marketing stunt common among failing small-cap stocks.

Dylan LeClair, director of market intelligence at digital asset fund UTXO Management also shared doubts, noting the plan would only work if there were legitimate demand for the equity sale.

Likely flops and is for PR purposes, he added.

If Nilam is successful, the company will hold more Bitcoin than any other publicly listed company in the United States, except for MicroStrategy.

Related: MicroStrategy sells another $604M of notes to buy 9K Bitcoin

That would include beating Elon Musks Tesla and major Bitcoin miners such as Riot Blockchain, Hut 8 Corp, and Marathon Digital Holdings, according to data from BitcoinTreasuries.

Former Nilam Resources CEO Ron McIntyre has also reportedly cried foul over the announcement, telling Protos that the press release was issued without his review and that he didnt have detailed knowledge of the deal.

Asked why he resigned from his position, McIntyre reportedly replied:

There will be a FINRA investigation into Nilam Resources, he added.

Nila Resources describes itself as an investment holding company. In November last year, it announced it would be pivoting from health and wellness investments to frontier tech including medtech, fintech, and climate tech.

It followed up just a day later with an announcement it had acquired TechyTrade, a fintech technology provider.

Nilam Resources did not immediately respond to a request for comment.

Magazine: Asia Express Am I sorry? No 3AC founder. $6B BTC laundered for fast food worker: Asia Express

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Nilam Resources flagged 'buyer beware' as shares pump over Bitcoin plans - Cointelegraph

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BlackRock says bitcoin will be a good portfolio diversifier despite its recent rally with stocks – CNBC

Posted: March 27, 2024 at 2:45 am

Bitcoin is more like digital gold than a so-called "risk-on" asset, according to Robert Mitchnick, BlackRock's digital assets lead. For years, bitcoin's ability to behave in different ways at different times has stumped investors . They believed the idea that it might be a hedge against inflation only to see the cryptocurrency tumble with stocks in 2022 amid sky-high inflation and rate hikes and then rally again as signs of cooling began to show. BlackRock's Mitchnick, speaking at the Bitcoin Investor Day conference in New York City on Friday, acknowledged that bitcoin has at times acted like a high-risk tech stock, but said that isn't how it typically trades. "Historically bitcoin's long-term average correlation [to stocks] has been close to zero slightly positive, but close to zero," he said. "It's had periods where it's spiked, similar to gold .... Actually, if you put their correlation charts in a time series, they look remarkably similar ." BTC.CM= YTD mountain Bitcoin (BTC) YTD "One of the most confusing, unhelpful things that happened in the post-Covid era was you had people accept this idea that bitcoin was a risk-on asset," he added. "Bitcoin is a risky asset it is volatile, has a lot of uncertainty. But 'risk on' is a different thing it implies correlation to equities [and] fixed income." Digital gold has become the dominant bitcoin narrative again in the past year, as the cryptocurrency's correlation with the S & P 500 returned to 2021 lows and even briefly flipped negative this January. While the recent rally was spurred by the launch of U.S. bitcoin exchange-traded funds, some on Wall Street have suggested that it may have recently fused into the more macroeconomic-fueled gold rally . @GC.1 YTD mountain Gold in 2024 There is an exception to that view, however, according to Mitchnick. "Bitcoin has one fundamental macro variable where it is highly correlated with equities: It is massively short real interest rates" (or the difference between nominal rates and inflation indicator) "and it is long inflation expectations," he said. "Real interest rates drove every asset under the sun between 2020 and early 2023," he added. "They collapsed, therefore a lot of assets including bitcoin rocketed, and then they surged as the Fed started hiking and inflation expectations rolled over." Risk and portfolio construction That, understandably, adds confusion for newcomers to bitcoin investing, who are drawn to its digital gold-like qualities. With so many new institutional investors becoming exposed to bitcoin through the ETFs particularly BlackRock's iShares Bitcoin Trust , which has pulled in nearly $8 billion of investor cash the cryptocurrency's correlations are "probably the single most important debate right now in thinking about bitcoin," Mitchnick said. "[Clients] are trying to understand: In a small allocation, is this risk additive to the portfolio or actually is it potentially a diversifier or even a hedge?" he said. "It also is important for any investor to understand because it's the reason that bitcoin's generally not appropriate in a large concentration in a portfolio," Mitchnick added. "In a large concentration, its volatility becomes a huge driver of risk, but in a more modest concentration, the fact that generally it's been uncorrelated and it has different fundamental drivers potentially becomes a different source of return and even in some cases, a diversifier." BlackRock clients who are allocating to bitcoin, including financial advisors on behalf of their clients and large institutions, tend to limit their exposure to between 1% and 3%, he said.

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BlackRock says bitcoin will be a good portfolio diversifier despite its recent rally with stocks - CNBC

Recommendation and review posted by G. Smith

Bitcoin maintains $70,000, and KuCoin charged with anti-money laundering violations – CNBC

Posted: March 27, 2024 at 2:45 am

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CNBC Crypto World features the latest news and daily trading updates from the digital currency markets and provides viewers with a look at what's ahead with high-profile interviews, explainers, and unique stories from the ever-changing crypto industry. On today's show, Paul Brody, global blockchain leader for EY, discusses the recent resurgence of crypto adoption and what to expect from Ethereum in the near future.

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Bitcoin maintains $70,000, and KuCoin charged with anti-money laundering violations - CNBC

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