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Category Archives: Longevity

Alejandro Bataller: life on the longevity frontier – Financial Times

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Roula Khalaf, Editor of the FT, selects her favourite stories in this weekly newsletter.

SHA Wellness Clinic is in the spotlight in the third talk of the Brains of Wellbeing + Beauty series, where we sit down with the scientists, entrepreneurs, innovators and disrupters powering the $5.6tn wellness industry.

The origins of this pioneering integrative health clinic began as a crazy and niche idea, says the companys vice-president Alejandro Bataller of his fathers decision to enter the wellness space by way of real estate 15 years ago. Here he speaks with HTSI editor Jo Ellison about Shas roots in Alicante, Spain, scaling up with new openings in Mexico and Abu Dhabi, and life on the longevity frontier. Can 100 be the new 80?

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Boosted immunity: Study reveals longevity of COVID-19 booster shots – News-Medical.Net

Thinking about getting a spring-time booster shot?A new studycoming out of York University's Centre for Disease Modelling in the Faculty of Science shows that immunity after a COVID-19 booster lasts much longer than the primary series alone. These findings are among other, sometimes "unintuitive," revelations of how factors like age, sex and comorbidities do and don't affect immune response.

The study's authorsYork Post Doctoral researchers Chapin Korosec and David Dick, Applied Mathematics Professor Iain Moyles and Professor James Watmough with the University of New Brunswickused health data submitted to the Covid Immunity Task-Force project for more than 150 individuals who received either Pfizer-BioNTechor Moderna COVID-19 vaccines to look at how immunity holds up over time.

Our approach as mathematicians is to create mathematical models of the immune system, and then calibrate those models to health care data in order to advance our understanding of the human immune system. It was really interesting to see the SARS-CoV-2 booster dose have such a huge increase in protective longevity capacity as compared to the primary series of two doses."

Chapin Korosec, study's lead author

Published today in the journalScientific Reports, the study used Canadian vaccine data collected from individuals living in long-term care, as well as frontline health-care workers working in long-term care and hospitals.

Looking at the group as a whole, the median length for the antibody half-life immune response was 63 days for the primary series, and increased to 115 days for those who went on to receive their boosters, a statistically significant finding, says Korosec.

It is well-established that age can affect how adept the body is at priming an immune response after vaccines, so much so that advanced age is considered a comorbidity itself, says Korosec.

"Chronological age is your time since birth. But you also have an immunological age, which is correlated to your chronological age, and is related to how your body loses its ability to prime against invading pathogens and produce antibodies as time marches on," explains Korosec. "What's convoluted is that as we age chronologically, the probability that we accrue diseases that can affect the immune system in unintuitive ways also increases."

Looking into this aspect, the researchers found that older adults did have a less long-lasting immune response, but once they controlled for other comorbidities such as hypertension, lung disease and cancer, age no longer had as significant of an influence on the immune response.

Other interesting findings include a small, but statistically significant immune response for males versus females, and people with asthma having a longer lasting immune response more durable, in fact, than those with hybrid immunity from vaccines and contracting COVID-19.

"We found that some outcomes were surprising and worth further study, but of course we're not advocating any particular comorbidity is beneficial," says Dick. "We don't have any information from this study on how asthma would affect the severity of the COVID-19 illness, for example."

Outside of the strict findings, the researchers also say the study points to the importance of interdisciplinary research and are excited about the possibilities for collaboration, with plans to open York's medical school in 2028.

"While we're all from math and stats departments, the data comes from clinicians who went through medical school and are now professors studying immunology, and I think this study shows how people with different skill sets can come together and do really interesting science," says Korosec.

Adds Moyles: "We have a really top applied math program at York, and now the university has announced a medical school. Imagine these clinicians were at York and we had access to the data on the ground floor. This would cut the research timeline by years and has huge potential for future interdisciplinary research at the university."

Source:

Journal reference:

Korosec, C. S., et al. (2024). SARS-CoV-2 booster vaccine dose significantly extends humoral immune response half-life beyond the primary series.Scientific Reports. doi.org/10.1038/s41598-024-58811-3

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Unlocking the secrets to longevity and wellness – CGTN

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"You cannot just focus on treating disease when they become a global problem, but try to prevent them and preventing people from becoming patients," Camillo Ricordi, director emeritus at the Diabetes Research Institute of the University of Miami, told CGTN in an interview.

He pointed out that our priority should be pursuing a healthy lifespan rather than simply aiming for longevity or lifespan, and noted that even small steps like regular exercise can feasibly promote a healthy lifespan.

For more tips on promoting a healthy lifespan, stay tuned for the full interview.

(Cover image designed by Liang Qian; video edited by Yu Rong)

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Americans favor quality over quantity in pursuit of longevity – PR Newswire

According to a new survey from Medtronic and Morning Consult, nearly two-thirds of U.S. adults say they'd opt for a shorter, healthier life than a longer one with health issues

DUBLIN, April 17, 2024 /PRNewswire/ -- Americans overwhelmingly say that when they think about longevity, it's more than just living longerit's about living their healthiest, best lives. While most want to live to 90well past the averageU.S. life expectancyof 77.5 yearsnearly two-thirds (66%) would choose a shorter, healthier life over a longer one with health issues. These findings, from a survey conducted by global healthcare technology leader Medtronic with Morning Consult, highlight a gap between U.S. adults' desire to live healthier years and the opportunity for more people to improve their quality of life through healthcare technology.

With almost limitless health-related information at our fingertips and new healthcare innovations emerging daily, the American dream of extending both our lifespan and quality of life seems possible. However, only 39% of U.S. adults say they are taking preventative health measures such as screenings and regular medical check-ups, and less than a third (29%) are discussing longevity with their doctor. Only about half are focused on eating healthy (53%) and exercising (51%), despite diet and physicalinactivity being leading contributors to chronic disease. And while 80% of Americans believe healthcare technology can help them live longer and healthier, only 18% are taking advantage of it.

"Health conditions can impact anyone at any age, so it's critical that we expand treatment options while also continuing to focus on prevention, so people can prioritize what's most important to them," said Dr. Laura Mauri, chief scientific, medical and regulatory officer at Medtronic. "The role of technology in helping people live longer and better lives is accelerating. It's enabling more personalized treatments, quicker recoveries and earlier diagnosis. What's more, every day researchers are discovering new technologies that continue to improve longevity and quality of life."

Perhaps the greatest power of technology is the range of optionsand hopeit can give people regardless of their current health status. Already, healthcare technology is helping catch cancer before it progresses, treat pain with less oral medication and reduce the burden from chronic diseases.

"In my 19 years as a diabetic, I feel more supported by my diabetes technology than I ever have before," said Cameron Moore, who uses a Medtronic insulin pump with meal detection technology. "It means I worry less about complications so I can focus on the here and now of life with my family and enjoy each day to the fullest."

There are steps people can take today to take charge of their health and live their best life. Follow the acronym T.E.C.H.:

For more information on how Medtronic is advancing healthcare through technology and helping people live longer and healthier, visit Medtronic.com.

About the Consumer Perceptions of Longevity SurveyThe survey was conducted by decision intelligence company Morning Consult among a nationally representative sample of 2,200 adults in the U.S. from February 15-20, 2024, with an unweighted margin of error of +/- 2 percentage points.

About MedtronicBold thinking. Bolder actions. We are Medtronic. Medtronic plc, headquartered in Dublin, Ireland, is the leading global healthcare technology company that boldly attacks the most challenging health problems facing humanity by searching out and finding solutions. Our Mission to alleviate pain, restore health, and extend life unites a global team of 95,000+ passionate people across more than 150 countries. Our technologies and therapies treat 70 health conditions and include cardiac devices, surgical robotics, insulin pumps, surgical tools, patient monitoring systems, and more. Powered by our diverse knowledge, insatiable curiosity, and desire to help all those who need it, we deliver innovative technologies that transform the lives oftwo people every second, every hour, every day. Expect more from us as we empower insight-driven care, experiences that put people first, and better outcomes for our world. In everything we do, we are engineering the extraordinary. For more information on Medtronic (NYSE:MDT), visit http://www.Medtronic.comand follow Medtronic on LinkedIn.

Any forward-looking statements are subject to risks and uncertainties such as those described in Medtronic's periodic reports on file with the Securities and Exchange Commission. Actual results may differ materially from anticipated results.

Contacts:

ErikaWinkels

RyanWeispfenning

Public Relations

Investor Relations

+1-763-526-8472

+1-763-505-4626

SOURCE Medtronic plc

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How Helldivers 2 Going into Cruise Control Can Benefit Its Longevity – GameRant

Highlights

Released in March 2015, the first Helldivers was a top-down co-op shooter that earned some impressive critical scores, landing it at an 83 on Metacritic. With a satirical Sci-Fi plot in a similar vein to Starship Troopers, some chaotically satisfying co-op gameplay, and an endless amount of replayability, the first Helldivers was well-deserving of its success. Nevertheless, its recently released sequel, Helldivers 2, blows it out of the water.

Taking its predecessor's general gameplay structure and narrative backbone, Helldivers 2 gives the series a modernized third-person shooter overhaul, along with the introduction of a live-service model. Still one of the most controversial elements of modern gaming, the live-service model has often resulted in the release of half-baked cash-grabs that receive minimal support after launch, but at the same time it's also produced some of the most successful, long-running games of all time. Thankfully, Helldivers 2 looks like it's on track to be part of the latter camp.

It's all too often that a live-service game will fail to meet expectations. Whether it's an unfinished story, a lack of compelling progression systems, a lack of post-launch support, or a mix of them all, many live-service games are doomed to fail from the get-go, and with the amount of effort that's required to keep them going for the long haul, many end up being shut down mere months after their initial release. But every so often, a live-service game comes out and proves that the model can not only work, but actually benefits the type of story and gameplay that the developer is going for. Helldivers 2 is the perfect example of that.

From the get-go, Helldivers 2 offered an impressive amount of content. Helldivers 2 came packaged with two major enemy factions, each coming with their own set of unique unit types and requiring different strategies to take down. Helldivers 2 also offers a robust set of progression systems, from unlockable weapons to Strategems to Ship Modules, the vast majority of which have a substantial purpose during gameplay, and feel genuinely satisfying to unlock.

But having enough content on day one is just the start for a live-service game. Thanks to games like Fortnite and Call of Duty: Warzone, players now expect any live-service game to receive frequent updates and content drops, and Helldivers 2 seems to be knocking it out of the park in this regard. In the last few months since launch, Helldivers 2 has added new Strategems, weapons, Warbonds, and enemy types on a fairly regular basis, all of which have been successful in convincing players to stick around. On top of this, Helldivers 2's general premise of an ever-evolving galactic war that sees players fight to control planets is a masterful integration of the live-service model, encouraging players to keep returning day after day to help conquer the galaxy.

Helldivers 2 seems to be thriving on its current live-service model, with a recent Bloomberg report suggesting that the game has sold at least 8 million copies so far. As things stand, the Helldivers 2 player-base seems more than satisfied with the amount of content currently in the game, and the pace at which new content is being added, meaning that there might not be a need for any kind of major expansion anytime soon.

With the Automatons fighting desperately to take back their home planet, rumors have started circulating that a new enemy faction, the Illuminate, could be introduced very soon, but it might be better if Helldivers 2 developer Arrowhead holds off on that. Rather than release a new faction or any kind of major expansion imminently, while players are still satisfied with the current pace of content, Helldivers 2 should save that big content drop for when it's really needed, when the initial hype surrounding the game eventually starts to die down.

Helldivers 2 is a third-person cooperative shooter developed by Arrowhead Games Studios for the PC and PlayStation 5 where players take control of a Helldiver set to protect the citizens of Super Earth by traveling to hostile alien worlds and destroying threats. Players undergo missions, defeat enemies, and use special items called Stratagems to help turn the tide of battle in this punishing release.

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Choosing Regular Food to Extend Longevity – CounterPunch.org – CounterPunch

Image by Brooke Cagle.

It is not often that a best-selling author and correspondent on consumer, food, medical, and health issues comes up with an idea for all Eaters that nobody has thought of before. Jean Carper, with sixty years of experience, has done just that with her brand-new book provocatively titled 100 Life or Death Foods: A Scientific Guide to Which Foods Prolong Life or Kill You Prematurely.

Based on scientific studies about the life-expectancy effect of different foods positive and negative (many cited in the books Appendix and available at the National Institutes of Health Library of Medicine). Carper writes: The evidence is stunningly clear that people who eat optimal diets can slow their aging process and add years to their lives.

Carper reports that researchers have found common legumes (beans, peas, soybeans), whole grains, and nuts, extend longevity, while refined grains (white bread), sugar-sweetened beverages, heavy salt use, and red and processed meats can shorten ones life.

Carpers book is instantly usable because she efficiently runs through specific foods. For example, studies give high life-extension marks to apples, bananas, beets, berries, cabbage, carrots, hot chili peppers, coffee, eggplant, fermented food (pickles and sauerkraut), garlic grapes and raisins, green leafy veggies, herbs and spices, kale, oats, olives and olive oil, brown rice, tea, tomatoes, vinegar, yogurt and whole grain cereals.

On the life-shortening side, she names alcoholic beverages, candy, diet sodas, cured meats (bacon, hot dogs), fried foods, ice cream, fruit juices (stripped of fiber and called high-calorie sugar water) ultra-processed foods, including those labeled with high amounts of sucrose, glucose, fructose, corn syrup, and refined sugary cereals that corporate hucksters advertise to youngsters.

In addition to specific foods, Carper explains why the Mediterranean Diet is so superior to the corporate Western Diet. She also praises the Dash Diet (similar to the Mediterranean Diet) which she reports as a famous blood pressure downer. She advocates getting your protein more from plants than from animals.

Much of the bad food cited in 100 Life or Death Foods is high on the list of the corporate marketeers who exploit taste and texture meaning sugar, salt, and fats to seduce children at a young age for a lifetime of ingesting junk food and junk drink. Their advertising is relentless, with heavy psychological manipulation. Fast food companies know from their own research the damage they have been doing to the health of their customers. That is why they fill their ads with lies and deceptions and have focused promotions on kiddy TV, over the decades.

The natural foods grown locally for generations have been mostly displaced by pesticide-heavy factory farms that fuel processed corporate diets.

This book is a guide for all eaters to work their way back to unprocessed natural foods, with organic-certified labels. These foods have another advantage they frequently come in at lower prices than steaks, chops, and highly processed foods, including those from fancy bakeries.

Carper recognizes, of course, that many factors influence life expectancy, such as genetics, exercise, lifestyles, smoking, pollution, alcohol abuse, and, of course, endemic poverty. Inadequate healthcare and health insurance also contribute to shortened life expectancies. However, food is something people can have personal control over without asking the permission of higher authorities.

Some people are in a position to grow their own vegetables and fruits and share the harvest with neighbors. Now you have what Carper calls a unique, up to date, one stop guide to more than 100 common foods, beverages and popular diets, revealing whether they prolong health and life or accelerate aging and death.

The guide works for all ages as well. It will show you that nutritious and delicious food prepared with all kinds of simple recipes can be healthy and tasty. (See,100 Life or Death Foods: A Scientific Guide to Which Foods Prolong Life or Kill You Prematurely, December 9, 2023).

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