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Category Archives: Gene Medicine

First gene therapy to go on sale in Europe in 2013: company

Dutch biotech company uniQure said Monday it would start selling the first human gene therapy to be approved in the West by mid-2013 and predicted an explosion of similar therapies to come. The European Commission approved Glybera on October 25, making the drug for treating the extremely rare disorder lipoprotein lipase deficiency (LPLD) the first to be approved for sale in Europe or North America. Continue reading →

Posted in Gene Medicine | Tagged a-chronic-lack, a-gene-therapy, development, europe-or-north, european, first, glybera, jesse-gelsinger, making-the-drug, medical, north-america-, relatively | Comments Off

Carnegie Institution and UMass Medical School granted broad US Patent related to RNA interference

Public release date: 16-Oct-2012 [ | E-mail | Share ] Contact: Tina McDowell tmcdowell@carnegiescience.edu 202-929-1120 Carnegie Institution Washington, D.C.The Carnegie Institution for Science and the University of Massachusetts Medical School (UMMS) have been granted United States Patent 8,283,329, entitled, “Genetic inhibition of double-stranded RNA.” The patent, issued on October 9, 2012, is broadly directed to the use of RNA interference (RNAi) to inhibit expression of a target gene in animal cells, including mammalian cells. The process by which RNA, the cellular material responsible for the transmission of genetic information, can silence a targeted gene within a living cell was discovered in 1998 by Carnegie’s Andrew Fire, (now a professor at Stanford University) and Craig C. Continue reading →

Posted in Gene Medicine | Tagged a-targeted-gene, dna, double-, massachusetts, office, school, science, target, technology, trademark, university, work | Comments Off

Two-gene test predicts which patients with heart failure respond best to beta-blocker drug

ScienceDaily (Oct. Continue reading →

Posted in Gene Medicine | Tagged a-blockers-for, a-given-patient, a-senior-author, a-two-gene-test, best, beta, denver, dna, international, study, united-states, university | Comments Off

2-gene test predicts which patients with heart failure respond best to beta-blocker drug

Public release date: 16-Oct-2012 [ | E-mail | Share ] Contact: Anne DeLotto Baier abaier@health.usf.edu 813-974-3303 University of South Florida (USF Health) Tampa, FL (Oct. 16, 2012) — A landmark paper identifying genetic signatures that predict which patients will respond to a life-saving drug for treating congestive heart failure has been published by a research team co-led by Stephen B. Continue reading →

Posted in Gene Medicine | Tagged a-given-patient, a-research-team, a-single-blood, genetic, knowledge, medical, medical-campus-, morsani-college | Comments Off

Nanoparticles seen as gene therapy advance

Published: Oct. 16, 2012 at 8:30 PM EVANSTON, Ill., Oct. 16 (UPI) — U.S. Continue reading →

Posted in Gene Medicine | Tagged been-developing, carry-healthy, combat-disease-, discovered-how, diseases, genetic, illnesses, other-illnesses, particles--, professor, professor-hai-, the-bloodstream, the-particles | Comments Off

Gene Linked to Kidney Failure

Reported by Julielynn Wong, MD A single gene may shed light on why more than half of transplanted kidneys fail in 10 years, a new study found. Continue reading →

Posted in Gene Medicine | Tagged a-failed-kidney, a-higher-risk, a-very-high, european, jordan, julielynn-wong, sinai-medical, stanley-jordan | Comments Off

Additive effect of small gene variations can increase risk of autism spectrum disorders

Public release date: 15-Oct-2012 [ | E-mail | Share ] Contact: Anita Srikameswaran 412-578-9193 University of Pittsburgh Schools of the Health Sciences PITTSBURGH, Oct. Continue reading →

Posted in Gene Medicine | Tagged autism-genome, bernie-devlin, california, health, impact-the-risk, medicine-their, michigan, pittsburgh, psychiatry, research, risk, scientists, simons-simplex, university | Comments Off

Dundee researchers link faulty gene to skin condition

Scottish researchers have uncovered the root causes of a skin complaint which affects thousands of people in the UK. Continue reading →

Posted in Gene Medicine | Tagged a-skin-complaint, have-uncovered, root, skin-complaint, the-root, uncovered-the-root, which-affects | Comments Off

Gene clues to help tackle skin disease

Dundee University experts said P34 played a key role in causing the disease punctate PPK, which gives sufferers dots of hard, thickened skin which can cause pain and discomfort. Irwin McLean, professor of human genetics in the Centre for Dermatology and Genetic Medicine at the university, said: “We have not only found this gene but we have been able to figure out how it works, which is very important Continue reading →

Posted in Gene Medicine | Tagged a-key-role, a-notable-step, a-possible-drug, centre, figure-out-how, human-genetics, nature, painful-lesions, skin | Comments Off

Shape matters in DNA nanoparticle therapy: Particles could become a safer, more effective delivery vehicle for gene …

ScienceDaily (Oct. 12, 2012) Researchers from Johns Hopkins and Northwestern universities have discovered how to control the shape of nanoparticles that move DNA through the body and have shown that the shapes of these carriers may make a big difference in how well they work in treating cancer and other diseases. This study, to be published in the Oct Continue reading →

Posted in Gene Medicine | Tagged applied-science, cells, computational, dna, johns-hopkins, journal, nanoparticle, paper, researchers, same, science, study, whiting-school | Comments Off

Gene Deletion Linked to Mental Illness, Obesity

By Traci Pedersen Associate News Editor Reviewed by John M. Grohol, Psy.D. on October 11, 2012 Researchers have pinpointed a small region in the genome the entirety of human hereditary information as a vital factor in the development of psychiatric disease and obesity Continue reading →

Posted in Gene Medicine | Tagged a-critical-role, a-small-region, a-vital-factor, archives, based-on-animal, dna, editor-reviewed, faculty, health, psychiatry, traci-pedersen | Comments Off

High Levels of Blood-Based Protein Specific to Mesothelioma

Fibulin-3 Represents a Sensitive and Specific Marker for the Diagnosis of Mesothelioma, Offering a Potential Tool for Early Diagnosis, Monitoring Newswise NEW YORK, October 11, 2012 Researchers at NYU School of Medicine have discovered the protein product of a little-known gene may one day prove useful in identifying and monitoring the development of mesothelioma in early stages, when aggressive treatment can have an impact on the progression of disease and patient prognosis. Continue reading →

Posted in Gene Medicine | Tagged a-simple-blood, conditions, department, development, england, medical, professor, research, researchers, study, surgery, weight-loss | Comments Off

Researchers Discover Gene Signature that Predicts Prostate Cancer Survival

Newswise Researchers from Mount Sinai School of Medicine have identified a six-gene signature that can be used in a test to predict survival in men with aggressive prostate cancer, according to new research published in the October issue of The Lancet Oncology. This is the first study to demonstrate how prognostic markers may be useful in a clinical setting. Using blood from 202 men with treatment-resistant prostate cancer, researchers found six genes characteristic of treatment-resistant prostate cancer Continue reading →

Posted in Gene Medicine | Tagged a-simple-blood, a-survival-time, boston, course, facebook, health, hematology, medical-school, medicine, mount, mount-sinai, school, world-report | Comments Off

Six-gene signature can predict survival in men with aggressive prostate cancer

Published on October 11, 2012 at 12:39 AM Researchers from Mount Sinai School of Medicine have identified a six-gene signature that can be used in a test to predict survival in men with aggressive prostate cancer, according to new research published in the October issue of The Lancet Oncology. This is the first study to demonstrate how prognostic markers may be useful in a clinical setting. Using blood from 202 men with treatment-resistant prostate cancer, researchers found six genes characteristic of treatment-resistant prostate cancer Continue reading →

Posted in Gene Medicine | Tagged a-simple-blood, a-survival-time, course, division, feasibility, medical, medicine, mount, mount-sinai, predictive, research, school, signature, study, without-it-were | Comments Off

Mount Sinai researchers discover gene signature that predicts prostate cancer survival

Public release date: 10-Oct-2012 [ | E-mail | Share ] Contact: Mount Sinai Press Office newsmedia@mssm.edu 212-241-9200 The Mount Sinai Hospital / Mount Sinai School of Medicine Researchers from Mount Sinai School of Medicine have identified a six-gene signature that can be used in a test to predict survival in men with aggressive prostate cancer, according to new research published in the October issue of The Lancet Oncology. This is the first study to demonstrate how prognostic markers may be useful in a clinical setting Continue reading →

Posted in Gene Medicine | Tagged a-simple-blood, a-survival-time, boston, course, division, medical-center, mount, press, research, signature, work | Comments Off

Gene signature predicts prostate cancer survival

ScienceDaily (Oct. 10, 2012) Researchers from Mount Sinai School of Medicine have identified a six-gene signature that can be used in a test to predict survival in men with aggressive prostate cancer, according to new research published in the October issue of The Lancet Oncology. Continue reading →

Posted in Gene Medicine | Tagged a-simple-blood, division, facebook, medicine, research, science, social-bookmarking, work | Comments Off

Rare Gene Deletion Tied To Psychiatric Disease And Obesity

Featured Article Academic Journal Main Category: Psychology / Psychiatry Also Included In: Obesity / Weight Loss / Fitness;Anxiety / Stress;Genetics Article Date: 10 Oct 2012 – 0:00 PDT Current ratings for: Rare Gene Deletion Tied To Psychiatric Disease And Obesity 4 (1 votes) 5 (1 votes) In their paper, Carl Ernst, a professor in the Department of Psychiatry at the Faculty of Medicine of McGill University in Montreal, Quebec, Canada, and colleagues, suggest deletion of BDNF, a nervous system growth factor that is important for brain development, leads to major depression, anxiety and obesity. They are confident they have found a molecular pathway that plays a key role in psychopathology. Ernst, who is also a researcher at the Douglas Mental Health University Institute (affiliated to McGill), says scientists have been scouring the genome to find regions in our DNA that may tell us something about the genetic origins of psychiatric disorders Continue reading →

Posted in Gene Medicine | Tagged article, children-, department, dna, europe-, fitness, genome, journal, medicine, participants, psychiatry, university, weight-loss | Comments Off

Test Spots Newborn Gene Disease

WASHINGTON (AP) Too often, newborns die of genetic diseases before doctors even know what is to blame. Now scientists have found a way to decode those babies’ DNA in just days instead of weeks, moving gene-mapping closer to routine medical care. Continue reading →

Posted in Gene Medicine | Tagged a-birth-defect, arthur-beaudet, baylor-college, blood, children-, dna, england, family, journal, kansas, medicine, science | Comments Off

2-day test can spot gene diseases in newborns

WASHINGTON (AP) – Too often, newborns die of genetic diseases before doctors even know what’s to blame. Now scientists have found a way to decode those babies’ DNA in just days instead of weeks, moving gene-mapping closer to routine medical care. Continue reading →

Posted in Gene Medicine | Tagged a-birth-defect, a-few-buttons, a-problem-with, a-single-gene, child, children-, dna, kansas, mapped-the-dna, mercy-hospital, science, study, tentative-first, wednesday, will-at-least | Comments Off

Gene diseases in newborns spotted with 2-day test

Too often, newborns die of genetic diseases before doctors even know what’s to blame. Now scientists have found a way to decode those babies’ DNA in just days instead of weeks, moving gene-mapping closer to routine medical care. Continue reading →

Posted in Gene Medicine | Tagged a-few-buttons, a-problem-with, a-speedy-new, children-, family, journal, kansas, said-it-signals | Comments Off

Rapid gene-mapping test may diagnose disease in newborns

WASHINGTONToo often, newborns die of genetic diseases before doctors even know what’s to blame. Now scientists have found a way to decode those babies’ DNA in just days instead of weeks, moving gene-mapping closer to routine medical care. The idea: Combine faster gene-analyzing machinery with new computer software that, at the push of a few buttons, uses a baby’s symptoms to zero in on the most suspicious mutations Continue reading →

Posted in Gene Medicine | Tagged become-the-true, children-, dna, family, hospital, mercy-hospital, science, time | Comments Off

Quicker gene test may help babies – Thu, 04 Oct 2012 PST

October 4, 2012 in Nation/World Lauran Neergaard Associated Press WASHINGTON Too often, newborns die of genetic diseases before doctors even know whats to blame. Now scientists have found a way to decode those babies DNA in just days instead of weeks, moving gene-mapping closer to routine medicalcare. Continue reading →

Posted in Gene Medicine | Tagged a-birth-defect, a-few-buttons, a-problem-with, a-single-gene, dna, hospital, kansas, kansas-city, study | Comments Off

Gene diseases in newborns unveiled quicker

WASHINGTON (AP) — Too often, newborns die of genetic diseases before doctors even know what’s to blame. Now scientists have found a way to decode those babies’ DNA in just days instead of weeks, moving gene-mapping closer to routine medical care. The idea: Combine faster gene-analyzing machinery with new computer software that, at the push of a few buttons, uses a baby’s symptoms to zero in on the most suspicious mutations. Continue reading →

Posted in Gene Medicine | Tagged a-birth-defect, a-few-buttons, a-speedy-new, become-the-true, blood, children-, dna, england, journal, kansas, kansas-city, results, science, ship-the-blood, time | Comments Off

Two-day test can spot gene diseases in newborns

WASHINGTON (AP) Too often, newborns die of genetic diseases before doctors even know what’s to blame. Continue reading →

Posted in Gene Medicine | Tagged a-birth-defect, a-few-buttons, a-single-gene, a-speedy-new, become-the-true, child, children-, dna, family, hospital, journal, kansas, science, study, time | Comments Off

Inherited Diseases Found Sooner in Newborns With DNA Scan

Scanning the DNA of sick infants using a new speed-reading method can diagnose rare genetic disorders in two days instead of weeks, according to research that brings gene mapping a step closer to everyday hospital use. Researchers at Childrens Mercy Hospitals and Clinics in Kansas City, Missouri, created software that takes raw data from DNA scanning machines and combs though hundreds of genetic disorders to spot disease-causing mutations. The system provided likely diagnoses for three of four sick babies in about two days, results published in Science Translational Medicine found Continue reading →

Posted in Gene Medicine | Tagged a-few-years, a-gene-test, a-similar-fast, a-step-closer, a-study-senior, childrens-mercy, david-dimmock, dna, institution, kansas, medical-college, results, science, study, technology | Comments Off