Testing curbs occurrence of some genetic diseases (The Bryan-College Station Eagle)

Some of mankind’s most devastating inherited diseases appear to be declining, and a few have nearly disappeared, because more people are using genetic testing to decide whether to have children.Births of babies with cystic fibrosis, Tay-Sachs and oth …

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For Predicting Alzheimer’s, the Eyes May Have It

Poor Eyesight in Later Years May Be Precursor to Alzheimer’s Development

Ignoring your eye problems may be one of the worst things you can do for your brain, never mind your eyes.

The problem with Alzheimer’s disease is that once it’s identified, the damage has already been done.  Treatments exist that slow its debilitating effects, but precious little can be done to reverse them.

As such, much of Alzheimer’s research is devoted to identifying Alzheimer’s disease before the symptoms are made manifest.  Well, researchers think they may—emphasis on may—have found a symptom that’s predictive of Alzheimer’s development.

According to a study published in the online edition of the American Journal of Epidemiology, a striking number of people who go on to develop Alzheimer’s have poor eyesight years ahead of diagnosis.  And people particularly vulnerable to its onset are those that don’t have it treated.

Researchers discovered this link after looking at the results of a 1992 health study involving 625 people approaching their senior citizen years.  Among other findings, the researchers found that 27 percent of them developed Alzheimer’s over an eight and a half year period.

Now, 27 percent is a pretty high figure all by itself, but what really took the researchers by surprise was how high the correlation was between a person’s eye health and Alzheimer’s development.

For example, 25 percent of people who said their vision was “fair” or “poor” at the start of the study eventually developed Alzheimer’s, while only 10 percent of the 168 with Alzheimer’s had “excellent” eyesight throughout.

But where things really got interesting was when researchers looked at whether those with poor eyesight ever got their eyes checked out by an opthamologist.  Of course, many did, but those that didn’t were nine times (!!) more likely to develop Alzheimer’s than those who sought and received treatment.

Researchers aren’t sure what it is about eyesight that portends Alzheimer’s development, but Dr. Mary A.M. Rogers, the study’s lead researcher, believes it may have something to do with the fact that untreated eyesight is a crippling condition in and of itself.  In other words, if you can’t see, you’re probably not going to be doing the things that keep your mind active, like travelling, reading, exercising.

Research has shown that an active brain can help prevent Alzheimer’s.

Now, as the University of Michigan researchers themselves say, this study does not definitively link eyesight trouble to Alzheimer’s development.  After all, a fairly high percentage (11 percent) of the participants had poor eyesight and maintained normal brain function throughout.  But the correlation is certainly intriguing and gives researchers something to further dissect regarding the physiological signs that point to Alzheimer’s development.

Further research will settle the findings, but this study points to the importance of eye health. It goes without saying that you should schedule annual visits with your opthamologist, but there are things you can take to maintain your eye health.

There are many different eye ailments (e.g., eye strain, astigmatisms, blurred vision, bloodshot eyes, etc.), but for the general maintenance of healthy eyes, take N-acetylcysteine, as it helps protect the eyes’ lenses; a multivitamin with selenium (selenium helps the body absorb antioxidants that fight eye-damaging free radicals); and vitamin A.  Vitamin A helps the eyes’ rods and cones adjust to contrasting conditions (i.e., transitioning from a light room to a dark room) and is fuel for the retina.

Sources:
reuters.com
newsmaxhealth.com
Balch, Phyllis A.  “Prescription for Nutritional Healing.”  4th Edition. 2006.  Avery:  New York

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Gene Therapy Reverses Effects of Lethal Childhood Muscle Disorder in Mice (Newswise)

Reversing a protein deficiency through gene therapy can correct motor function, restore nerve signals and improve survival in mice that serve as a model for the lethal childhood disorder spinal muscular atrophy, new research shows.

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Study: Gene therapy reverses effects of lethal childhood muscle disorder in mice (EurekAlert!)

( Ohio State University ) Reversing a protein deficiency through gene therapy can correct motor function, restore nerve signals and improve survival in mice that serve as a model for the lethal childhood disorder spinal muscular atrophy, new research shows. This muscle-wasting disease results when a child’s motor neurons — nerve cells that send signals from the spinal cord to muscles — produce …

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Gene links to celiac disease may help drug search (Reuters via Yahoo! News)

Scientists have identified new genetic links to celiac disease and say their findings could speed the search for better ways to diagnose and treat the gluten-intolerance disorder.

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The Genetic Disease Foundation (GDF) Encourages Americans to Know Their Genes at KnowYourGenes.org in Observance of … (redOrbit)

NEW YORK, Feb.

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Genetic Disease Foundation Encourages Americans to Know Their Genes at KnowYourGenes.org in Observance of World Rare … (PRWeb)

Survey finds Americans willing to undergoing genetic testing, but few taking action (PRWeb Feb 28, 2010) Read the full story at http://www.prweb.com/releases/2010/02/prweb3660374.htm

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Shocking Public Announcements Ads

These wonderful PSA ads were all singled out for their shock factor and creativity, and they certainly are something to look at! As far as I can tell, they are part of a french exhibition that focused on 6 big humanitarian causes. There are 150 in total, posters as well as films, and you can check out the whole bunch HERE!  Totally worth a gander, some real creativity there.

[via leblogdebango]

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COX-2 inhibitor can prevent "religious headache" during fast

Every year, millions of observant Jews fast on their holiest day, Yom Kippur, and millions of Muslims fast for the month of Ramadan. And every year, as many as 40% of those who fast develop serious headaches.

Yom Kippur headache is a well documented phenomenon but the causes are unclear, but doctors have suspected withdrawal from caffeine, nicotine, oversleeping, and dehydration.

About 36% of subjects who took COX-2 inhibitor etoricoxib (related to Vioxx) developed headaches, compared to about 68% who took placebo. Those who took etoricoxib also had less severe headaches, and they had an easier time fasting.

References:
Could Vioxx cousin prevent religious fast headache? WebMD.

Image source: Etoricoxib, Wikipedia, public domain.

Posted at Clinical Cases and Images. Stay updated and subscribe, follow on Twitter and Buzz, and connect on Facebook.


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Genetic Disease Foundation Encourages Americans to Know Their Genes at KnowYourGenes.org in Observance of World Rare … (PRWeb via Yahoo! News)

Survey finds Americans willing to undergoing genetic testing, but few taking action

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Autistic people are dangerous weirdoes, just like Gordon Brown

Autistic people are dangerous weirdoes, just like Gordon Brown.  Or that is what you could think if you read the musings of political journalists.

This blog has often bemoaned the state of modern day journalism with respect to the obvious quackeries of homeopathy, nutritionism and chiropractic where sensational claims are treated with all the skepticism of the Catholic Church on the miracles of Padre Pio.  But this is nothing compared to political journalism, where quackery is not so much proselytised as practiced.  Every political journalist considers themselves an expert on the character of politicians and for some it seems this expertise is coupled with that on the pathology of mental health.

Here’s Minette Marin in The Sunday Times:

Recently a story emerged that Brown was being prescribed powerful antidepressants; the allegation was never substantiated so it was dropped. But what struck me was the widespread view at the time that a prime minister should not be asked about his mental health. That is nonsense. Significant depression, obsessive-compulsive disorder, personality disorders and autism-spectrum disorders all can and do profoundly affect a person’s judgment and behaviour in disastrous ways. All are difficult, and some impossible, to treat. It is clearly in the public interest to know whether our prime minister is suffering from any of these disabilities.

The First Post, via Simon Heffer

There have been rumours about Brown’s health and mental state for several years, of course. In 2004, Simon Heffer wrote in the Spectator that the PM displayed many signs of Asperger’s Syndrome, including obsessional behaviour patterns and humourlessness.

And Janet Daley in The Telegraph

Once again I am compelled to ask the question, “Is Gordon Brown quite mad?” This is not vulgar abuse. We must consider the possibility at this point that the Prime Minister is technically delusional.

All this without submerging one’s head in the Great Stink of the political blogosphere, where the noxious stench of bile and verbal diarrhoea surely cries out for a modern day Bazalgette to channel this vile effluence away from the seats of power.

Political journalism and political blogging have now reduced the Government and the Houses of Parliament to little more than a modern day Bedlam where sneering critics can flaunt their ignorance and display their amorality by diagnosing, without recourse to expertise or professionalism, the mental state of its wretched inhabitants.

Can we talk about policies instead?

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Inhibition of Cell Proliferation of Tenon’s Capsule Fibroblast by S-Phase Kinase-Interacting Protein 2 Targeting SiRNA through Increasing p27 Protein Level [Glaucoma]

Skp2 siRNA inhibited cell proliferation and decreased cell viability of rTF in vivo and in vitro. SiRNA-mediated gene silencing of Skp2 can be a novel gene therapy to treat scarring after glaucoma surgery by the suppression of p27kip1 downregulation. (Source: Investigative Ophthalmology)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed – updated hourly from thousands of authoritative health and news sources.

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Enhanced anti-tumor effects of combined MDR1 RNA interference and human sodium/iodide symporter (NIS) radioiodine gene therapy using an adenoviral system in a colon cancer model

Enhanced anti-tumor effects of combined MDR1 RNA interference and human sodium/iodide symporter (NIS) radioiodine gene therapy using an adenoviral system in a colon cancer model

Cancer Gene Therapy advance online publication, February 26, 2010. doi:10.1038/cgt.2010.3

Authors: S J Ahn, Y H Jeon, Y J Lee, Y L Lee, S-W Lee, B-C Ahn, J-H Ha
& J Lee (Source: Cancer Gene Therapy)

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Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation

Authors: M C Whelan, G Casey, M MacConmara, J A Lederer, D Soden, J K Collins, M Tangney
& G C O’Sullivan (Source: Cancer Gene Therapy)

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Gene Mutation in Mice Sheds Light on Autism

Drugs targeting obsessive behavior might hold promise for people

Source: HealthDay
Related MedlinePlus Pages: Autism, Genes and Gene Therapy (Source: MedlinePlus Health News)

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A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model

Inhibiting the expression of the HIV-1 coreceptor CCR5 holds great promise for controlling HIV-1 infection in patients. Here we report stable knockdown of human CCR5 by a short hairpin RNA (shRNA) in a humanized bone marrow/liver/thymus (BLT) mouse model. We delivered a potent shRNA against CCR5 into human fetal liver-derived CD34+ hematopoietic progenitor/stem cells (HPSCs) by lentiviral vector transduction. We transplanted vector-transduced HPSCs solidified with Matrigel and a thymus segment under the mouse kidney capsule. Vector-transduced autologous CD34+ cells were subsequently injected in the irradiated mouse, intended to create systemic reconstitution. CCR5 expression was down-regulated in human T cells and monocytes/macrophages in systemic lymphoid tissues, including gut-associated…

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Woman shares abortion experience live on Twitter, YouTube

NEW YORK – A woman took to her Twitter page to tell all about the abortion she was going through – step by step.

Angie Jackson, 27, wanted to “demystify” abortion, and so shared it on Twitter, YouTube and her personal blog.
“I’m doing this so other women know, ‘Hey, it’s not nearly …. Source  : Woman shares abortion experience live on Twitter, YouTube.

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Ed Miliband becomes latest victim of ‘Twitterjacking’ scam

LONDON – British Labour politician Ed Miliband has become the latest victim to have his Twitter account hacked by wrongdoers who are bent on embarrassing politicians.

The ‘Twitterjacking’ scam has caught out a series of politicians including the Leader of the House of Commons, Harriet Harman.
It was supposed to be … Read this article on Gaea Times at : Ed Miliband becomes latest victim of ‘Twitterjacking’ scam.

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National Conference demands apology from Opposition for Facebook slur

Jammu, Feb 27 (ANI): The ruling National Conference has demanded an apology from the state’s main opposition People’s Democratic Party (PDP) for depicting three generations of the Abdullah family as ‘3 Idiots’ on social networking site Facebook.

Finance Minister Abdul Rahim Rather slammed the PDP for ’stooping low … Read : National Conference demands apology from Opposition for Facebook slur.

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Hawaii newspaper deal may lead to Honolulu becoming single-newspaper town

For sale: a newspaper in paradise
HONOLULU — Honolulu barely escaped becoming a one-newspaper town about a decade ago. Many believe the death of one its two dailies is inevitable this time around.

The parent company of the Honolulu Star-Bulletin announced Thursday it was purchasing longtime rival The Honolulu Advertiser, the largest newspaper in Hawaii, and would … Original source on Gaea Times at : Hawaii newspaper deal may lead to Honolulu becoming single-newspaper town.

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Is the Latest Union Budget a Good or Bad News for Indian IT Industry?

 Although, 2010-11 Union Budget has brought some good news for the construction, hospitality, banking, education and pharma sectors, but, it does not generate any good news for IT industry. The Finance minister didn’t mention anything about the extension of Tax Rebate in this budget for IT industries.

Since, the tax break ends in Mar 2011, outsourcing …. Source article  : Is the Latest Union Budget a Good or Bad News for Indian IT Industry?.

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Wisconsin senator critical of NBC handling of online access to Olympics

Kohl critical of NBC online Olympic coverage

WASHINGTON — A Democratic senator criticized NBC on Friday for its handling of online access to the Vancouver Olympics, calling it unfair and restrictive.
Sen. Herb Kohl of Wisconsin, chairman of the Senate Judiciary Committee’s antitrust panel, wrote NBC Universal Chief Executive Jeff Zucker to complain about an NBC policy …. Original article  : Wisconsin senator critical of NBC handling of online access to Olympics.

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Twitter prodding users to update settings to create more ways for people to find each other

Twitter wants users to update their personal info

SAN FRANCISCO — Twitter is prodding its users to update their personal settings to create more ways for people to connect on its communications service.
The request will pop up when Twitter users log into their accounts.
Some accountholders have already seen the information boxes, labeled “Be found on Twitter.”
A …. Original source  : Twitter prodding users to update settings to create more ways for people to find each other.

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VMWare buys EMC information technology management business for $200 million

VMWare buys EMC IT management business for $200M

PALO ALTO, Calif. — VMware Inc. will acquire part of EMC Corp.’s Ionix information technology management business for $200 million in cash.
Under the terms of the deal, EMC will retain the Ionix brand and full reseller rights.
The deal is expected to close in the second quarter.
Shares of VMware, … Read the original article on Gaea Times at : VMWare buys EMC information technology management business for $200 million.

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Summary Box: Cheaper computers and software bring special effects even to amateur movies

Summary Box: Being a home special effects wizard

HOMEMADE EFFECTS: Movies popping up online have explosions, spaceships and other visual effects that once had been possible only for big Hollywood studios.
TECHNOLOGY’S MARCH: The falling costs of computing power, effects software and cameras are making it easier for everyday people to augment homemade videos.
DEDICATION REQUIRED: Producing the … Read more >>>.

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