Treat Gestational Diabetes for Baby’s Sake

Treating pregnant women who have even mild gestational diabetes helps reduce the risk of complications in infants and the women’s own risk of blood pressure problems, according to a new study.

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Only 1/3 in U.S. Plan to Get Swine Flu Vaccine

Only a third of Americans plan to get the swine flu vaccine. One reason: 57% of those at risk of severe flu don’t know it, a Consumer Reports poll shows.

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Strep Throat: No Link Seen to Tourette’s Syndrome, Tics, or OCD

Streptococcal infections such as strep throat and strep pneumonia don’t appear to make Tourette’s syndrome, tics, or obsessive-compulsive disorder more likely.

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Bacteria Have Role in Swine Flu Deaths

Bacterial co-infections play a role in swine flu deaths. Most of these are vaccine-preventable pneumococcus infections. Some are deadly MRSA.

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CDC: Alarming Increase in Methadone Deaths

The growing use of methadone for pain relief is largely responsible for a dramatic increase in deaths linked to the drug, which have risen sevenfold in less than a decade, an alarming government report shows.

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Breast Cancer Deaths Drop Again

Breast cancer death rates continue to drop by 2% a year. Despite the decline, African-American women die of breast cancer 40% more often than white women.

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Step forward for nanotechnology: Controlled movement of molecules (PhysOrg)

Scientists in the United Kingdom are reporting an advance toward overcoming one of the key challenges in nanotechnology: Getting molecules to move quickly in a desired direction without help from outside forces. Their achievement has broad implications, the scientists say, raising the possibility of coaxing cells to move and grow in specific directions to treat diseases.

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Gordon Brown makes unhelpful comment on cancer

All the political blogs are busy interpreting the nuance and debating the policy implications of Gordon Brown’s speech to the Labour conference.  I’ll leave them to do that.  I have a major issue with this particular part of his speech though:

And because we know that our investment in breast cancer screening works and early intervention saves lives, I am proud to announce that we will go much further.

We will finance a new right for cancer patients to have diagnostic tests carried out, completed and with results – often same day results – within one week of seeing your GP. That is our early diagnosis guarantee, building on our current guarantee of only two weeks wait to see a specialist.

And so with three major steps forward – early diagnosis, early treatment and our historic investment in research for cancer cures, we in Britain can transform cancer care; and our ambition is no less than to beat cancer in this generation

My bold.

Sadly it is a myth that there is a cure for cancer and that cancer can be beaten in a generation.  The best succinct explanation I have seen of this is from PHD comics (below).  I’m all for politicians making arguments for more research and healthcare, I’m less keen on them distorting public perception of the results of that research and healthcare.  It bothers me somewhat that this speech without doubt underwent a substantial number of revisions and likely had contributions from many individuals and not a single one of them noticed that this claim about cancer was remarkable.

http://www.phdcomics.com/comics.php?f=1162 (copyright Jorge Cham)

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Step forward for nanotechnology: Controlled movement of molecules (EurekAlert!)

( American Chemical Society ) Scientists in the United Kingdom are reporting an advance toward overcoming one of the key challenges in nanotechnology: Getting molecules to move quickly in a desired direction without help from outside forces. The study is scheduled for the October issue of ACS Nano, a monthly journal.

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Why Cleanse the Bowel ?

A good cleansing program should always begin by removing the waste in your colon, the last portion of your food processing chain. If you attempt to clean your liver, blood, or lymph system without first addressing a waste filled bowel, the excreted toxins will only get recycled back into your body.

One of the most frequent bowel problems that people experience today is constipation. Constipation is generally attributed to a low fiber diet and lack of sufficient water, which cause our fecal matter to become condensed and compressed.

A constipated system is one in which the transition, or “time”, of toxic wastes is slow and the consistency of the stool can cause strain (which over time may cause hemorrhoids, varicose veins, hiatal hernia, or other mechanically induced problems). The longer the “transit time”, the longer the toxic waste matter sits in our bowel which allows proteins to putrefy, fats to rancify, and carbohydrates to ferment. Read more…

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Nanotechnology And Synthetic Biology: What Does The American Public Think? (Medical News Today)

Nanotechnology and synthetic biology continue to develop as two of the most exciting areas of scientific discovery, but research has shown that the public is almost completely unaware of the science and its applications. A groundbreaking poll of 1,001 American adults conducted by Peter D.

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Nanotechnology Company to Announce Breakthroughs (PR Newswire via Yahoo! Finance)

PharmaNova, a leader in nanotechnology-based Drug Delivery Systems, is due to exhibit at the 2009 annual meeting of the American Association of Pharmaceutical Scientists scheduled in Los Angeles, CA, from November 8 – 12.

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Best websites for Kindle (mobile) – please add more

This is a list of some of the best websites for Kindle (mobile) – please add more to the wiki at Google Docs – it is open to anybody to edit http://j.mp/kindle33

Best Websites for Kindle – mobile
(please add more below)

NYTimes
http://m.nytimes.com

WSJ
http://m.wsj.com

USA Today
http://m.usatoday.com

CNN
http://m.cnn.com

FT
http://m.ft.com

Reuters
http://m.reuters.com

Google Mobilizer (makes websites mobile-friendly)
http://google.com/gwt/n

Gmail
http://m.gmail.com

Skweezer (makes websites mobile-friendly)
http://skweezer.com

TIME
http://mobile.time.com

Twitter
http://m.twitter.com

Video: What Can Amazon Kindle 2 Do for You?

Image source: Amazon.com.

Posted at Clinical Cases and Images. Stay updated and subscribe, or follow me on Twitter.


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Pre-test: Check to see if you have the brain for science

Do not take this seriously.

Pre-test: Check to see if you have the brain for science. Do you understand what this PubMed abstract is about? http://bit.ly/zkbss

(trans-1,4-bis[(4-pyridyl)ethenyl]benzene)(2,2′-bipyridine)ruthenium(II) complexes and their supramolecular assemblies with beta-cyclodextrin.

Toma SH, Uemi M, Nikolaou S, Tomazela DM, Eberlin MN, Toma HE.

Inorg Chem. 2004 May 31;43(11):3521-7.

Two novel ruthenium polypyridine complexes, [Ru(bpy)(2)Cl(BPEB)](PF(6)) and ([Ru(bpy)(2)Cl](2)(BPEB))(PF(6))(2) (BPEB = trans-1,4-bis[2-(4-pyridyl)ethenyl]benzene), were synthesized and their characterization carried out by means of elemental analysis, UV-visible spectroscopy, positive ion electrospray (ESI-MS), and tandem mass (ESI-MS/MS) spectrometry, as well as by NMR spectroscopy and cyclic voltammetry. Cyclic and differential pulse voltammetry for the mononuclear complex showed three set of waves around 1.2 V (Ru(2+/3+)), -1.0 V (BPEB(0/)(-)), and -1.15 (BPEB(-/2-)). This complex exhibited aggregation phenomena in aqueous solution, involving pi-pi stacking of the planar, hydrophobic BPEB ligands. According to NMR measurements and variable-temperature experiments, the addition of beta-cyclodextrin (betaCD) to [Ru(bpy)(2)Cl(BPEB)](+) leads to an inclusion complex, breaking down the aggregated array.

Image source: OpenClipArt.org, public domain.

Posted at Clinical Cases and Images. Stay updated and subscribe, or follow me on Twitter.


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A First General Solubility Model from ONS Challenge Data

After about a year, the Open Notebook Science Solubility Challenge has resulted in over 680 measurements, with about an additional 100 from the literature. Taking into account averaged repeated measurements, discarding some erroneous results and considering only organic solids (so far all of our liquid solutes have proven to be miscible in our solvents), that leaves us with 244 unique values.

Andrew Lang has created a general model (Model003) to predict solubility based on molecular descriptors of both the solutes and solvents. Previous models, such as Rajarshi Guha’s Model002 were built only for selected solvents.

Predictions can be made from this web page by entering the SMILES of the solute and optionally the SMILES, dipole moment and dielectric constant of any solvent (convenient sources for these are Wolfram Alpha and Wikipedia). Boc-glycine with diethyl ether as an optional solvent is shown here.
The prediction service then looks up the relevant molecular descriptors from the CDK and makes predictions for some common solvents and the optional one if requested.

If the name of the solute was entered, the service will also report all of the experimental measurements for that solute from the ONS Challenge with links to the lab notebook pages.

There are a few objectives in making this public.

First, we think that it might provide some ideas about possible good or bad solvents for a given solute. The dataset is certainly not large enough to provide a truly general prediction of solubility in absolute terms. However, comparing relative values might be helpful in many cases. In the example above for boc-glycine, the model predicts that toluene would be the poorest solvent, which matches the order of the experimental values, even if the absolute values are not a close match. DMSO, THF, methanol and ethanol are predicted to be good solvents and this is reflected in the measurements.

Second, we want to make the model and data public so that other researchers with experience in this area can contribute their own models. We have been working with Marcin Wojnars from TunedIT to make it much easier for models to be submitted. Andy has just converted our dataset to ARFF format and it is available here. We should have more to report on this shortly.

By using molecular descriptors from the solvents we should be able to do predictions for solvent mixtures as well. At some point perhaps we can even include temperature.

The current model fits measurement with this type of distribution:
If we are able to build models automatically in real time after the addition of each data point, we should be able to set up automatic solubility measurement requests to minimize the amount of work it takes to improve each model. This is a step in that direction.

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Grey’s Anatomy Promotional Pictures: "I Always Feel Like Somebody’s Watchin’ Me"

After an emotional season premiere, the gang is settling into their lives post-George.

How will that go?

Below are some promotional photos released by ABC for this Thursday’s all-new episode of Grey’s Anatomy, entitled “I Always Feel Like Somebody’s Watchin’ Me.”

There appears to be plenty of drama, as well as some baseball being played.

Click to enlarge the photos below and tell us what you think

McHandsomeCristowen PicWig StyleYou Call That a STRIKE?!Squaring to BuntBaseballKarev and Stevens PictureA Funny SceneA Tense MomentDr. Karev PictureDer and Mer Love

Follow the jump for more pictures …

The Surgical Team in ActionOn the DiamondMer and Der LoveAll Hands Are on DeckBatter Up!Owenstina PicWigginGone!

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Mike Mitchell

Mike Mitchell

Mike Mitchell

Mike Mitchell

Mike Mitchell

These fabulous pieces were made by illustrator Mike Mitchell. By the looks of it they seem to be all digital, which is mighty impressive! I love the color and pop they have, especially the hummingbird, and the subtlety of the skull in the last image is also very well done. Be sure to check out more of his awesome work HERE! (don’t forget the blog, too!)

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Body Maintenance

Clever advertising series for Toyota car service/maintenance by Harshad Badbe.  We’ve seen this a lot before, but I still think it’s a very cool spine execution! Would love to see a brain too…

[via Behance]

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NIH New Innovator Award Won By M. D. Anderson Scientist For Innovative Research In Drug Resistance

A unique approach to understanding how cells develop resistance to drugs has won a scientist at The University of Texas M. D. Anderson Cancer Center a New Innovator Award from the National Institutes of Health. Gábor Balázsi, Ph.D., assistant professor in M. D. Anderson’s Department of Systems Biology, will receive $1.5 million over five years under the highly competitive program.

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Anti-Aging Medicine A Growing Experience

Address:314 North Paxtang Ave.
Zip:17111
City:Harrisburg Anti-Aging Medicine
See all Anti-Aging Medicine in Pennsylvania

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Your Life “D”pends on It

Study:  Elderly Low in Vitamin D Increase their Risk of Premature Death

Natural sunlight is among the best sources of Vitamin D.

Natural sunlight is among the best sources of Vitamin D.

Some “D”pressing news to report on the heart health front, particularly if you’re a senior citizen.  According to a joint study conducted by researchers from Colorado and Massachusetts, the elderly are at greater risk of dying from heart disease when their vitamin D levels are low.

If you feel like you’ve been bombarded with vitamin D news lately, you’re not alone.  The media are great at beating a dead horse, aren’t they?  But this time the “beating” is warranted, as they’ve finally come to the realization that vitamin D really is the “D”fensive vitamin.

Just how defensive?  Well if the Colorado and Massachusetts researchers’ findings are accurate, and there’s no reason to think that they aren’t, if you’re not sufficiently armed with D, you’re three times more likely to die from heart disease.

This truly “D”sturbing finding (OK, OK, I’ll quit with the “D” stuff) was published in the Journal of the American Geriatrics Society after researchers reviewed the health statistics of approximately 3,400 people in their elder years (65 years and older).  In the course of reviewing their blood samples, they found that those with the lowest vitamin D levels were three times more likely to have died than those with high vitamin D levels.  They were also two-and-a-half times more likely to have died from other diseases not including heart disease.

The researchers came from the University of Colorado and Boston’s Massachusetts General Hospital.

As I’ve referenced in past articles, health officials have increased the recommended dosage for vitamin D, but only for the youngest among us (i.e. toddlers, young children), not the estimated 24 million elderly currently living in America.  Perhaps this latest report will serve as sufficient justification to up the recommended dosage (400 to 600 IUs is what’s recommended for men and women over 50).

In the meantime, it’s important to expose your skin to the sunlight.  Generally speaking, the elderly are loath to spend all the livelong day in the sun.  But I’m not talking all day; I’m talking about 20 to 25 minutes of direct sunlight exposure (no sunscreen).  That’s all that’s needed to get a sufficient dose of the sunshine vitamin (if possible, stay out in the sun in the 25 minute range rather than 20 minutes; the skin becomes less absorbent of the sun’s rays as we age).

You can get a good amount of vitamin D through the food you eat, but there aren’t many options to choose from.  Pasteurized milk and other dairy products are usually fortified with vitamin D, but that’s not enough for me to start advocating pasteurized milk consumption (see why here).

That pretty much leaves fish as the best option for vitamin D through food.  Salmon—perhaps the most nutritious protein source on planet Earth—has about 350 IUs of vitamin D in a 3.5 ounce portion.  Mackerel is another fish that’s loaded with D (about 345 IUs per 3.5 ounce serving).

Whether it’s through the sun’s rays or the fish that you graze, get this vital vitamin in your system—your life “d”pends on it.

Sources:
sciencedaily.com
dietary-supplements.info.nih.gov

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The Fullness Factor

Why Certain Fatty Foods Fall Flat in Satisfying Our Appetite

Certain kinds of food fail to satisfy the appetite.

Certain kinds of food fail to satisfy the appetite.

Ever notice how foods loaded with fat never leave you satisfied, while low fat foods leave you feeling fuller longer?

Fat has more calories than carbohydrates and proteins (nine calories per gram as opposed to four calories per gram), so it’s natural to assume that high fat foods will leave us feeling more satiated than foods that are lower in fat.  Typically this is true, but not for the potato chip snacker or for the Pillsbury plunderer.  Dollars to doughnuts, these snack attackers will tell you it’s not true, as one doughnut, one chip, is never enough (a single Krispy Kreme doughnut has 12 grams of fat).

Several factors play into this dietary conundrum, one of which is whether or not what you’re consuming has any fiber in it.  Fiber plays a huge role in what I like to call “the fullness factor,” as high fiber foods are digested slower, and high fiber foods take up more room in the stomach.

But there’s another factor to consider that researchers have only recently keyed into, and its name is palmitic acid.

Palmitic acid is a saturated fatty acid found primarily in dairy foods like milk, cheese, butter, and milk.  Many of these ingredients are used in the production of bakery items like doughnuts, so it’s no wonder doughnuts never leave us feeing satisfied.

To study palmitic acid’s effects on appetite and brain chemistry, researchers fed a group of rats various kinds of fat.  Some of them were fed palmitic acid, while others were fed oleic acid, which is an unsaturated fatty acid found primarily in vegetable oils like olive oil.  They were fed these oils intravenously.

After three weeks, the researchers found that the rats fed the palmitic acid consistently ate more than the rats fed the oleic acid.

The researchers chalk up this fat find to palmitic acid’s ability to chemically alter the brain.  When palmitic acid is consumed in high enough quantities, it triggers the release of a certain protein that effectively renders leptin and insulin useless.  Leptin and insulin are hormones that help regulate appetite.  Among other functions, they tell the brain when the body feels “full.”

The study was published in the Journal of Clinical Investigation and conducted by scientists from the University of Texas Southwestern Medical Center.

As a natural health advocate— and you, a natural health follower— scarfing on doughnuts and snicker doodles to test the scientists’ findings is not the best of idea.  However, I mention this study because each and every one of us “cheats” now and then, so it’s helpful to understand why certain “cheat” foods leave us feeling full, while others leave us feeling flat or unsatisfied.

Besides the kinds of food we’re eating, we also need to take into consideration how fast we’re eating.  As I wrote in a past Mangano Minute, there’s about a 20 minute delay between our brain and stomach in recognizing whether or not we feel full.  That’s why people who are trying to lose weight are advised to eat slower.  Eating slower not only enables the brain to recognize that fullness factor, but it also helps us enjoy our foods a bit more.  And enjoyment is the second most important thing in our daily dinings, the most important one being nutrition, of course.

Sources:
foodnavigator.com
krispykreme.com

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Slowing the Pace of Muscle Waste

Despite Age, Weight Training Slows Muscle Loss

Regardless of age, weightlifting reduces muscle loss

Regardless of age, weightlifting reduces muscle loss

The noted poet Robert Frost once said, “In three words, I can sum up everything I know about life:  It goes on.”

How true.  No matter our condition, no matter how difficult or easy our circumstances are, life continues on.

Perhaps the best illustration of this truism is observing one’s exercise regimen once they reach their thirties and forties.

For example, I’ve been an avid exerciser since I was young, but as I’ve grown older, I’ve noticed how I’m not as quick as I used to be, I’m not the same strapping  young lad that I was in my mid-twenties.

But what’s changed?  I’m still pretty much the same weight. I definitely eat better than I used to eat.  So why are my exercise pursuits floundering instead of flourishing?

Obviously the passage of time and age is the answer to this question, but just what is it about age that forces us to recognize our lifting limits?

Well, researchers believe they may have found the answer to that question, and the answer is written in their blood.

By this I mean that as we age, like our decrease in muscle mass, blood flow efficiency decreases as well.

Researchers affirmed this sad fact of life after testing was done on a group of active twentysomethings and sixtysomethings.  Their blood was tested prior to their having breakfast and then tested again afterward.  Each of them were then given a shot of insulin to see whether or not insulin was used differently in the participants’ bloodstream, suspecting it would be used differently depending on their age.

Just as the good doctors’ suspected, insulin was used differently, and as you may have already guessed, insulin was used more efficiently in the young folks’ bodies.

Insulin is something of a renaissance hormone – it has many roles and many talents.  One of them is in regulating how much glucose the blood feeds to the muscles.  As the researchers found, the twentysomethings had a greater blood flow and insulin response in the muscles observed, while there wasn’t much of a change observed in the older group.

The study is published in the American Journal of Clinical Nutrition and was performed by researchers from the University of Nottingham in England.

So, as we age, do we just have to grin and bear our depleting physiques?  Must we be resigned to the notion that we’re no longer our twentysomething selves?

Yes and no.

Yes, we do have to accept that life goes on and our strength does decrease, but we can slow the aging process though our exercise efforts.

As researchers found in a follow-up study, the older men that weightlifted regularly used insulin more efficiently and saw more muscle growth than those that didn’t lift.  In fact, the insulin response and increased blood flow was on par with the twentysomethings!

The researchers define “regular” as weightlifting three times a week.  That’s exactly my idea of “regular” as well, for I weight train three times a week (though I’ll occasionally miss a session or two due to work constraints).

So there you have it.  Life may go on, but you can make sure it goes slowly through moderate amounts of weight training every week.

Sources:
livescience.com
wisegeek.com

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Food In Real Life

The pictures on packages make the food inside look so delicious. The sauces are just the right thickness and the vegetables glisten in studio lights. But, you have to wonder,…

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Homewood employees to keep merit raises, longevity pay in 2010 (Birmingham News)

City Council finance committee had recommended cutting merit and longevity pay.

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